Toggle Main Menu Toggle Search

Open Access padlockePrints

Exploration of the impact of 'mild phenotypes' on median age at death in the UK CF registry

Lookup NU author(s): Professor Dawn Teare


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Background The widespread availability of genetic testing allowing the identification of "milder" individuals with CF coincided with improvements in CF life expectancy but the relative contribution of case mix to that improved survival is uncertain. Methods Patients in the UK CF registry were divided into 'mild phenotype' defined as pancreatic sufficient and 'typical CF' defined as pancreatic insufficient. Distributions of age at death were compared with Mann-Whitney test. Temporal trends in incidence and prevalence were described. Jonckheere-Terpstra test was used to compare the trend for median age at death from 2007 to 2010. Results Patients with 'mild phenotype' had significantly higher age at death (32 years, interquartile range 14 years versus 27 years, interquartile range 29 years; Mann-Whitney test p-value = 0.026). The proportion of patients with 'mild phenotype' appeared to be increasing (0.128 in 2007, 0.144 in 2010). The trend for increasing age at death (from 25 years in 2007 to 29 years in 2010, Jonckheere-Terpstra test p-value = 0.012) was independent of the 'mild phenotype' patients. Conclusion The impact of mild phenotypes on the improvement in the median age at death among people with CF was trivial. © 2014 Elsevier Ltd. All rights reserved.

Publication metadata

Author(s): Hoo ZH, Wildman MJ, Teare MD

Publication type: Article

Publication status: Published

Journal: Respiratory Medicine

Year: 2014

Volume: 108

Issue: 5

Pages: 716-721

Print publication date: 01/05/2014

Online publication date: 12/03/2014

Acceptance date: 19/02/2014

ISSN (print): 0954-6111

ISSN (electronic): 1532-3064

Publisher: W.B. Saunders Ltd


DOI: 10.1016/j.rmed.2014.02.012

PubMed id: 24675238


Altmetrics provided by Altmetric