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© 2019 Stelmes, Gregoire, Poorten, Golusiñski, Szewczyk, Jones, Ansarin, Broglie, Giger, Klussmann, Evans, Bourhis, Leemans, Spriano, Dietz, Hunter, Zimmermann, Tinhofer, Patterson, Quaglini, Govaerts, Fortpied and Simon.Dysphagia represents one of the most serious adverse events after curative-intent treatments with a tremendous impact on quality of life in patients with head and neck cancers. Novel surgical and radiation therapy techniques have been developed to better preserve swallowing function, while not negatively influencing local control and/or overall survival. This review focuses on the current literature of swallowing outcomes after curative treatment strategies. Available results from recent studies relevant to this topic are presented, demonstrating the potential role of new treatment modalities for early-and intermediate-stage oropharyngeal cancers. Based on this, we present the rationale and design of the currently active EORTC 1420 “Best of” trial, and highlight the potential of this study to help prioritizing either surgery-or radiation-based treatment modalities for the treatment of oropharyngeal cancer in the future.
Author(s): Stelmes J-J, Gregoire V, Poorten VV, Golusinski W, Szewczyk M, Jones T, Ansarin M, Broglie MA, Giger R, Klussmann JP, Evans M, Bourhis J, Leemans CR, Spriano G, Dietz A, Hunter K, Zimmermann F, Tinhofer I, Patterson JM, Quaglini S, Govaerts A-S, Fortpied C, Simon C
Publication type: Article
Publication status: Published
Journal: Frontiers in Oncology
Year: 2019
Volume: 9
Online publication date: 22/10/2019
Acceptance date: 17/09/2019
ISSN (electronic): 2234-943X
Publisher: Frontiers Research Foundation
URL: https://doi.org/10.3389/fonc.2019.00999
DOI: 10.3389/fonc.2019.00999
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