Toggle Main Menu Toggle Search

Open Access padlockePrints

Organ preservation and late functional outcome in oropharyngeal carcinoma: Rationale of EORTC 1420, the “best of” trial

Lookup NU author(s): Dr Joanne Patterson


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


© 2019 Stelmes, Gregoire, Poorten, Golusiñski, Szewczyk, Jones, Ansarin, Broglie, Giger, Klussmann, Evans, Bourhis, Leemans, Spriano, Dietz, Hunter, Zimmermann, Tinhofer, Patterson, Quaglini, Govaerts, Fortpied and Simon.Dysphagia represents one of the most serious adverse events after curative-intent treatments with a tremendous impact on quality of life in patients with head and neck cancers. Novel surgical and radiation therapy techniques have been developed to better preserve swallowing function, while not negatively influencing local control and/or overall survival. This review focuses on the current literature of swallowing outcomes after curative treatment strategies. Available results from recent studies relevant to this topic are presented, demonstrating the potential role of new treatment modalities for early-and intermediate-stage oropharyngeal cancers. Based on this, we present the rationale and design of the currently active EORTC 1420 “Best of” trial, and highlight the potential of this study to help prioritizing either surgery-or radiation-based treatment modalities for the treatment of oropharyngeal cancer in the future.

Publication metadata

Author(s): Stelmes J-J, Gregoire V, Poorten VV, Golusinski W, Szewczyk M, Jones T, Ansarin M, Broglie MA, Giger R, Klussmann JP, Evans M, Bourhis J, Leemans CR, Spriano G, Dietz A, Hunter K, Zimmermann F, Tinhofer I, Patterson JM, Quaglini S, Govaerts A-S, Fortpied C, Simon C

Publication type: Article

Publication status: Published

Journal: Frontiers in Oncology

Year: 2019

Volume: 9

Online publication date: 22/10/2019

Acceptance date: 17/09/2019

ISSN (electronic): 2234-943X

Publisher: Frontiers Research Foundation


DOI: 10.3389/fonc.2019.00999


Altmetrics provided by Altmetric