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Uniformity of cardiac 123I-MIBG uptake on SPECT images in older adults with normal cognition and patients with dementia

Lookup NU author(s): Gemma Roberts, Dr James LloydORCiD, Elizabeth Jefferson, Dr Rory Durcan, Dr Sarah Lawley, Dr George Petrides, Dr Ifti Haq, Professor John O'Brien, Professor Alan ThomasORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Some studies report that assessing regional 123I-cardiac MIBG uptake can aid in the diagnosis of Lewy body disease, but others report heterogeneity in healthy controls. We aimed to evaluate regional cardiac MIBG uptake patterns in healthy older adults and patients with dementia.31 older adults with normal cognition, 15 Alzheimer’s disease (AD), and 17 Dementia with Lewy bodies (DLB) patients were recruited. 5 individuals had previous myocardial infarction. Participants with sufficient cardiac uptake for regional SPECT analysis (29/31 controls, 15/15 AD, 5/17 DLB) had relative uptake pattern recorded. Controls were assessed for risk of future cardiovascular events using QRISK2, a validated online tool.In controls uptake was reduced in the inferior wall (85%), apex (23%), septum (15%), and lateral wall (8%). AD and DLB showed similar patterns to controls. Lung or liver interference was present in 61% of cases. Myocardial infarction cases showed regional reductions in uptake, but normal/borderline planar uptake. In controls, there was no relationship between cardiovascular risk score and uptake pattern.Significant variability of regional cardiac 123I-MIBG uptake is common in cases with normal planar cardiac uptake. Heterogeneity of regional uptake appears non-specific and unlikely to aid in the diagnosis of Lewy body disease.

Publication metadata

Author(s): Roberts G, Lloyd JJ, Jefferson E, Kane JPM, Durcan R, Lawley S, Petrides GS, Howe K, Haq I, O'Brien JT, Thomas AJ

Publication type: Article

Publication status: Published

Journal: Journal of Nuclear Cardiology

Year: 2019

Pages: ePub ahead of Print

Online publication date: 09/12/2019

Acceptance date: 18/11/2019

Date deposited: 12/12/2019

ISSN (print): 1071-3581

ISSN (electronic): 1532-6551

Publisher: Springer


DOI: 10.1007/s12350-019-01977-5


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