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Lookup NU author(s): Gemma Roberts, Dr James LloydORCiD, Elizabeth Jefferson, Dr Rory Durcan, Dr Sarah Lawley, Dr George Petrides, Dr Ifti Haq, Professor John O'Brien, Professor Alan ThomasORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Some studies report that assessing regional 123I-cardiac MIBG uptake can aid in the diagnosis of Lewy body disease, but others report heterogeneity in healthy controls. We aimed to evaluate regional cardiac MIBG uptake patterns in healthy older adults and patients with dementia.31 older adults with normal cognition, 15 Alzheimer’s disease (AD), and 17 Dementia with Lewy bodies (DLB) patients were recruited. 5 individuals had previous myocardial infarction. Participants with sufficient cardiac uptake for regional SPECT analysis (29/31 controls, 15/15 AD, 5/17 DLB) had relative uptake pattern recorded. Controls were assessed for risk of future cardiovascular events using QRISK2, a validated online tool.In controls uptake was reduced in the inferior wall (85%), apex (23%), septum (15%), and lateral wall (8%). AD and DLB showed similar patterns to controls. Lung or liver interference was present in 61% of cases. Myocardial infarction cases showed regional reductions in uptake, but normal/borderline planar uptake. In controls, there was no relationship between cardiovascular risk score and uptake pattern.Significant variability of regional cardiac 123I-MIBG uptake is common in cases with normal planar cardiac uptake. Heterogeneity of regional uptake appears non-specific and unlikely to aid in the diagnosis of Lewy body disease.
Author(s): Roberts G, Lloyd JJ, Jefferson E, Kane JPM, Durcan R, Lawley S, Petrides GS, Howe K, Haq I, O'Brien JT, Thomas AJ
Publication type: Article
Publication status: Published
Journal: Journal of Nuclear Cardiology
Year: 2019
Pages: ePub ahead of Print
Online publication date: 09/12/2019
Acceptance date: 18/11/2019
Date deposited: 12/12/2019
ISSN (print): 1071-3581
ISSN (electronic): 1532-6551
Publisher: Springer
URL: https://doi.org/10.1007/s12350-019-01977-5
DOI: 10.1007/s12350-019-01977-5
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