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Lookup NU author(s): Professor Yen Nee Tan
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Hybrid nanoparticles (NPs) have emerged as an important class of nanomaterials owing to their integrated enhanced properties and functionality. In this study, we have developed an effective nanodot templating strategy for the in situ formation of surfactant-free nanohybrids with unique plasmonic-fluorescent properties. A bright photoluminescent biodot synthesized from serine and histamine biomolecular precursors (Ser–Hist dot) was first engineered to have rich functional groups on the nanosurface capable of anchoring Ag+ ions via electrostatic interaction. Upon UV irradiation, free electrons could transfer from the photoexcited Ser–Hist dot to the Ag+ ions, facilitating the in situ growth of AgNPs. The resulting nanohybrid system (Bio@AgNPs) exhibits distinct characteristic surface plasmon resonance absorbance and highly quenched PL intensity due to the inner filter effect. Furthermore, the Bio@AgNP nanohybrid retains its redox capability, enabling hydrogen peroxide sensing via AgNP etching, which in turn empowers a dual colorimetric and fluorescent detection of glucose and cholesterol in complex biological samples (i.e., synthetic urine and human plasma) with high selectivity and sensitivity. This finding reveals a new effective and facile method for the preparation of highly functional hybrid nanomaterials for dual-mode detection of hydrogen peroxide-producing species and/or reactions.
Author(s): Xu HV, Zhao Y, Tan YN
Publication type: Article
Publication status: Published
Journal: ACS Applied Material & Interfaces
Year: 2019
Volume: 11
Issue: 30
Pages: 27233-27242
Print publication date: 31/07/2019
Online publication date: 08/07/2019
Acceptance date: 08/07/2019
ISSN (print): 1944-8244
ISSN (electronic): 1944-8252
Publisher: American Chemical Society
URL: https://doi.org/10.1021/acsami.9b08708
DOI: 10.1021/acsami.9b08708
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