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Is JmjC Oxygenase Catalysis Limited to Demethylation?

Lookup NU author(s): Professor Akane Kawamura

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Abstract

Substrate selectivity studies indicate that members of the biomedically important JmjC demethylase family of histone N^ε‐methyllysine demethylases are capable of catalyzing the de‐N‐alkylation of groups other than N‐methyl and can catalyze reactions that form stable hydroxylated products. The differences in binding preferences in this set of enzymes may be helpful in the design of selective inhibitors.

Publication metadata

Author(s): Hopkinson RJ, Walport LJ, Münzel M, Rose NR, Smart TJ, Kawamura A, Claridge TDW, Schofield CJ

Publication type: Article

Publication status: Published

Journal: Angewandte Chemie International Edition

Year: 2013

Volume: 55

Issue: 30

Pages: 7709-7713

Print publication date: 22/07/2013

Online publication date: 17/07/2013

ISSN (print): 1433-7851

ISSN (electronic): 1521-3773

Publisher: Wiley-VCH Verlag GmbH & Co. KGaA

URL: https://doi.org/10.1002/anie.201303282

DOI: 10.1002/anie.201303282

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