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Lookup NU author(s): Dr Paul Donaghy,
Dr Michael FirbankORCiD,
Professor Alan ThomasORCiD,
Dr James LloydORCiD,
Dr George Petrides,
Professor John O'Brien
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
Objective: Significant amyloid deposition is present in approximately half of all cases of dementia with Lewy bodies (DLB). We sought to determine whether amyloid deposition was associated with more rapid clinical decline over one year. Methods28 participants had a baseline clinical assessment and amyloid PET scan, followed by a further clinical assessment after one year. Changes in clinical measures were compared with amyloid deposition assessed by visual rating and cortical standardized uptake value ratio (SUVR). Results: Amyloid deposition on visual rating was associated with greater decline in MMSE and daily function over one year. There was no correlation between cortical SUVR and clinical measures. Conclusions: This study provides further evidence for a link between amyloid deposition and clinical progression in DLB. Pathologies such as amyloid, and their interaction with α-synuclein, remain possible treatment targets in DLB.
Author(s): Donaghy PC, Firbank MJ, Thomas AJ, Lloyd J, Petrides G, Barnett N, Olsen K, O'Brien JT
Publication type: Article
Publication status: Published
Journal: American Journal of Geriatric Psychiatry
Print publication date: 01/05/2020
Online publication date: 23/12/2019
Acceptance date: 18/12/2019
Date deposited: 30/12/2019
ISSN (print): 1064-7481
ISSN (electronic): 1545-7214
Publisher: Elsevier Inc.
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