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Amyloid imaging and longitudinal clinical progression in dementia with Lewy bodies

Lookup NU author(s): Dr Paul Donaghy, Dr Michael FirbankORCiD, Professor Alan ThomasORCiD, Dr James LloydORCiD, Dr George Petrides, Nicola Barnett, Kirsty OlsenORCiD, Professor John O'Brien

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Abstract

Objective: Significant amyloid deposition is present in approximately half of all cases of dementia with Lewy bodies (DLB). We sought to determine whether amyloid deposition was associated with more rapid clinical decline over one year. Methods28 participants had a baseline clinical assessment and amyloid PET scan, followed by a further clinical assessment after one year. Changes in clinical measures were compared with amyloid deposition assessed by visual rating and cortical standardized uptake value ratio (SUVR). Results: Amyloid deposition on visual rating was associated with greater decline in MMSE and daily function over one year. There was no correlation between cortical SUVR and clinical measures. Conclusions: This study provides further evidence for a link between amyloid deposition and clinical progression in DLB. Pathologies such as amyloid, and their interaction with α-synuclein, remain possible treatment targets in DLB.

Publication metadata

Author(s): Donaghy PC, Firbank MJ, Thomas AJ, Lloyd J, Petrides G, Barnett N, Olsen K, O'Brien JT

Publication type: Article

Publication status: Published

Journal: American Journal of Geriatric Psychiatry

Year: 2020

Volume: 28

Issue: 5

Pages: 573-577

Print publication date: 01/05/2020

Online publication date: 23/12/2019

Acceptance date: 18/12/2019

Date deposited: 30/12/2019

ISSN (print): 1064-7481

ISSN (electronic): 1545-7214

Publisher: Elsevier Inc.

URL: https://doi.org/10.1016/j.jagp.2019.12.009

DOI: 10.1016/j.jagp.2019.12.009

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