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Associations with photoreceptor thickness measures in the UK Biobank

Lookup NU author(s): Professor David SteelORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2019, The Author(s).Spectral-domain OCT (SD-OCT) provides high resolution images enabling identification of individual retinal layers. We included 32,923 participants aged 40–69 years old from UK Biobank. Questionnaires, physical examination, and eye examination including SD-OCT imaging were performed. SD OCT measured photoreceptor layer thickness includes photoreceptor layer thickness: inner nuclear layer-retinal pigment epithelium (INL-RPE) and the specific sublayers of the photoreceptor: inner nuclear layer-external limiting membrane (INL-ELM); external limiting membrane-inner segment outer segment (ELM-ISOS); and inner segment outer segment-retinal pigment epithelium (ISOS-RPE). In multivariate regression models, the total average INL-RPE was observed to be thinner in older aged, females, Black ethnicity, smokers, participants with higher systolic blood pressure, more negative refractive error, lower IOPcc and lower corneal hysteresis. The overall INL-ELM, ELM-ISOS and ISOS-RPE thickness was significantly associated with sex and race. Total average of INL-ELM thickness was additionally associated with age and refractive error, while ELM-ISOS was additionally associated with age, smoking status, SBP and refractive error; and ISOS-RPE was additionally associated with smoking status, IOPcc and corneal hysteresis. Hence, we found novel associations of ethnicity, smoking, systolic blood pressure, refraction, IOPcc and corneal hysteresis with photoreceptor thickness.

Publication metadata

Author(s): Chua SYL, Dhillon B, Aslam T, Balaskas K, Yang Q, Keane PA, Tufail A, Reisman C, Foster PJ, Patel PJ, Bishop PP, Barman PSA, Barrett PJH, Blows MP, Bunce DC, Carare DRO, Chakravarthy PU, Chan DM, Crabb PDP, Cumberland MPM, Day DA, Desai DP, Sudlow PC, Dick PAD, Egan DC, Ennis PS, Fruttiger DM, Gallacher DJEJ, Garway-Heath PDF, Gibson DJ, Gore MD, Guggenheim PJA, Hammond PCJ, Hardcastle PA, Harding PSP, Hogg DRE, Hysi DP, Khaw PSPT, Khawaja DAP, Lascaratos DG, Lotery PAJ, Macgillivray DT, Mackie DS, Martin PK, Mcgaughey MM, Mcguinness DB, Mckay DGJ, Mckibbin MM, Mitry DD, Moore PT, Morgan PJE, Muthy MZA, O'Sullivan ME, Owen DCG, Paterson ME, Peto DT, Petzold DA, Rahi PJS, Rudnicka DAR, Self DJ, Sivaprasad PS, Steel MD, Stratton MI, Strouthidis DN, Thaung DC, Thomas DD, Trucco PE, Vitart DV, Vernon PSA, Viswanathan DAC, Williams DC, Williams DK, Woodside PJV, Yates DMM, Yip DJ, Zheng DY, Tapp DR

Publication type: Article

Publication status: Published

Journal: Scientific Reports

Year: 2019

Volume: 9

Issue: 1

Online publication date: 19/12/2019

Acceptance date: 22/10/2019

Date deposited: 15/01/2020

ISSN (electronic): 2045-2322

Publisher: Nature Publishing Group


DOI: 10.1038/s41598-019-55484-1

PubMed id: 31857628


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