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Lookup NU author(s): Laura Powell,
Professor John Sayer
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© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.The primary cilium and the immunological synapse are both specialized functional plasma membrane domains that share several similarities. Signalling output of membrane domains is regulated, spatially and temporally, by segregating and focusing lipids and proteins. ARL3, a small GTPase, plays a major role in concentrating lipid-modified proteins in both the immunological synapse and the primary cilia. Here in this review we will introduce the role of ARL3 in health and disease and its role in polarizing signalling at the primary cilia and immunological synapses.
Author(s): Powell L, Samarakoon YH, Ismail S, Sayer JA
Publication type: Review
Publication status: Published
Journal: Small GTPases
Pages: ePub ahead of print
Online publication date: 18/12/2019
Acceptance date: 11/12/2019
ISSN (print): 2154-1248
ISSN (electronic): 2154-1256
Publisher: Taylor and Francis Inc.
PubMed id: 31826708