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ARL3, a small GTPase with a functionally conserved role in primary cilia and immune synapses

Lookup NU author(s): Laura Powell, Professor John SayerORCiD

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Abstract

© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.The primary cilium and the immunological synapse are both specialized functional plasma membrane domains that share several similarities. Signalling output of membrane domains is regulated, spatially and temporally, by segregating and focusing lipids and proteins. ARL3, a small GTPase, plays a major role in concentrating lipid-modified proteins in both the immunological synapse and the primary cilia. Here in this review we will introduce the role of ARL3 in health and disease and its role in polarizing signalling at the primary cilia and immunological synapses.

Publication metadata

Author(s): Powell L, Samarakoon YH, Ismail S, Sayer JA

Publication type: Review

Publication status: Published

Journal: Small GTPases

Year: 2021

Volume: 12

Issue: 3

Pages: 167-176

Online publication date: 11/12/2019

Acceptance date: 08/12/2019

ISSN (print): 2154-1248

ISSN (electronic): 2154-1256

Publisher: Taylor and Francis Inc.

URL: https://doi.org/10.1080/21541248.2019.1703466

DOI: 10.1080/21541248.2019.1703466

PubMed id: 31826708

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