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Cocaine-associated atypical haemolytic uraemic syndrome in a genetically susceptible individual

Lookup NU author(s): Professor David KavanaghORCiD

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This is the authors' accepted manuscript of an article that has been published in its final definitive form by Wiley-Blackwell Publishing Ltd., 2020.

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Abstract

Atypical haemolytic uraemic syndrome (aHUS) is a severe, life-threateningcondition that requires early recognition and urgent treatment. In aHUS rare genetic variantsin CFH, CFI, CD46, C3 and CFB predispose to complement over activation. This casedescribes a case of aHUS in which there was a strong temporal association between diseaseonset and the use of smoked cocaine. The patient was found to have a rare genetic variant inthe CFI gene which may have been unmasked by first-time exposure to cocaine. The patientstabilised and improved with early administration of eculizumab, supporting the notion of anunderlying immunological pathogenesis and the importance of early intervention.

Publication metadata

Author(s): Bongetti E, Kavanagh D, Martin K, Bendall A, Hill P, Steinberg A, Rajaram Y, Ierino F

Publication type: Article

Publication status: Published

Journal: Nephrology

Year: 2020

Volume: 25

Issue: 7

Pages: 518-521

Print publication date: 01/07/2020

Online publication date: 04/01/2020

Acceptance date: 02/12/2019

Date deposited: 06/01/2020

ISSN (print): 1320-5358

ISSN (electronic): 1440-1797

Publisher: Wiley-Blackwell Publishing Ltd.

URL: https://doi.org/10.1111/nep.13690

DOI: 10.1111/nep.13690

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