Toggle Main Menu Toggle Search

Open Access padlockePrints

Pathways to cellular supremacy in biocomputing

Lookup NU author(s): Dr Lewis Grozinger, Ruud Stoof, Dr Harold Fellermann, Dr Paolo Zuliani, Dr Angel Goni-Moreno


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Synthetic biology uses living cells as the substrate for performing human-defined computations. Many current implementations of cellular computing are based on the “genetic circuit” metaphor, an approximation of the operation of silicon-based computers. Although this conceptual mapping has been relatively successful, we argue that it fundamentally limits the types of computation that may be engineered inside the cell, and fails to exploit the rich and diverse functionality available in natural living systems. We propose the notion of “cellular supremacy” to focus attention on domains in which biocomputing might offer superior performance over traditional computers. We consider potential pathways toward cellular supremacy, and suggest application areas in which it may be found.

Publication metadata

Author(s): Grozinger L, Amos M, Gorochowski TE, Carbonell P, Oyarzún DA, Stoof R, Fellermann H, Zuliani P, Tas H, Goñi-Moreno A

Publication type: Article

Publication status: Published

Journal: Nature Communications

Year: 2019

Volume: 10

Print publication date: 20/11/2019

Online publication date: 20/11/2019

Acceptance date: 29/10/2019

ISSN (electronic): 2041-1723

Publisher: Nature Publishing


DOI: 10.1038/s41467-019-13232-z


Altmetrics provided by Altmetric