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Effect of Recanalization on Cerebral Edema in Ischemic Stroke Treated With Thrombolysis and/or Endovascular Therapy

Lookup NU author(s): Dr Anand Dixit

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Abstract

Background and Purpose- A large infarct and expanding cerebral edema (CED) due to a middle cerebral artery occlusion confers a 70% mortality unless treated surgically. Reperfusion may cause blood-brain barrier disruption and a risk for cerebral edema and secondary parenchymal hemorrhage (PH). We aimed to investigate the effect of recanalization on development of early CED and PH after recanalization therapy. Methods- From the SITS-International Stroke Treatment Registry, we selected patients with signs of artery occlusion at baseline (either Hyperdense Artery Sign or computed tomography/magnetic resonance imaging angiographic occlusion). We defined recanalization as the disappearance of radiological signs of occlusion at 22 to 36 hours. Primary outcome was moderate to severe CED and secondary outcome was PH on 22- to 36-hour imaging scans. We used logistic regression with adjustment for baseline variables and PH. Results- Twenty two thousand one hundred eighty-four patients fulfilled the inclusion criteria (n=18 318 received intravenous thrombolysis, n=3071 received intravenous thrombolysis+thrombectomy, n=795 received thrombectomy). Recanalization occurred in 64.1%. Median age was 71 versus 71 years and National Institutes of Health Stroke Scale score 15 versus 16 in the recanalized versus nonrecanalized patients respectively. Recanalized patients had a lower risk for CED (13.0% versus 23.6%), adjusted odds ratio (aOR), 0.52 (95% CI, 0.46-0.59), and a higher risk for PH (8.9% versus 6.5%), adjusted odds ratio, 1.37 (95% CI, 1.22-1.55), than nonrecanalized patients. Conclusions- In patients with acute ischemic stroke, recanalization was associated with a lower risk for early CED even after adjustment for higher rate for PH in recanalized patients.


Publication metadata

Author(s): Thoren M, Dixit A, Escudero-Martinez I, Gdovinova Z, Klecka L, Rand V-M, Toni D, Vilionskis A, Wahlgren N, Ahmed N

Publication type: Article

Publication status: Published

Journal: Stroke

Year: 2020

Volume: 51

Issue: 1

Pages: 216-223

Print publication date: 01/01/2020

Online publication date: 10/12/2019

Acceptance date: 02/10/2019

ISSN (print): 0039-2499

ISSN (electronic): 1524-4628

Publisher: American Heart Association

URL: https://doi.org/10.1161/STROKEAHA.119.026692

DOI: 10.1161/STROKEAHA.119.026692

PubMed id: 31818228


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