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Lookup NU author(s): Professor Alastair BurtORCiD
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
© The Author(s) 2016. It is currently known that colorectal cancers (CRC) arise from 3 different pathways: the adenoma to carcinoma chromosomal instability pathway (50%-70%); the mutator Lynch syndrome route (3%-5%); and the serrated pathway (30%-35%). The World Health Organization has classified serrated polyps into three types of lesions: hyperplastic polyps (HP), sessile serrated adenomas/polyps (SSA/P) and traditional serrated adenomas (TSA), the latter two strongly associated with development of CRCs. HPs do not cause cancer and TSAs are rare. SSA/P appear to be the responsible precursor lesion for the development of cancers through the serrated pathway. Both HPs and SSA/Ps appear morphologically similar. SSA/P are difficult to detect. The margins are normally inconspicuous. En bloc resection of these polyps can hence be troublesome. A careful examination of borders, submucosal injection of a dye solution (for larger lesions) and resection of a rim of normal tissue around the lesion may ensure total eradication of these lesions.
Author(s): Singh R, Zorron Cheng Tao Pu L, Koay D, Burt A
Publication type: Review
Publication status: Published
Journal: World Journal of Gastroenterology
Online publication date: 14/09/2016
Acceptance date: 31/07/2016
ISSN (print): 1007-9327
ISSN (electronic): 2219-2840
Publisher: Baishideng Publishing Group Co., Limited
PubMed id: 27678358