Toggle Main Menu Toggle Search

Open Access padlockePrints

Fungi at the Scene of the Crime: Innocent Bystanders or Accomplices in Oral Infections?

Lookup NU author(s): Dr Christopher NileORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2018, The Author(s).Purpose of Review: Over the last decade, microbiome studies have enhanced our knowledge and understanding of the polymicrobial nature of oral infections. Recently, profiling of the fungal microbiome has expanded our conventional understanding of oral ecology, revealing the critical importance of yeasts within this complex microbiome. This review aims to explore our current appreciation of interkingdom interactions in oral disease. Recent Findings: There is a growing evidence base of interactions and pathogenic synergy and antagonism with bacterial species within oral disease. Recent studies have helped to develop our knowledge of how Candida albicans, alongside bacteria such as Porphyromonas gingivalis, Streptococcus mutans, Staphylococcus aureus, Enterococcus faecalis, and Lactobacillus species, influence overall pathogenicity. Summary: Clinical and experimental evidence makes a compelling case for a role for C. albicans in a number of oral infections, though whether its role is an active accomplice or passive bystander remains to be determined.

Publication metadata

Author(s): Delaney C, Kean R, Short B, Tumelty M, McLean W, Nile CJ, Ramage G

Publication type: Review

Publication status: Published

Journal: Current Clinical Microbiology Reports

Year: 2018

Volume: 5

Issue: 3

Pages: 190-200

Online publication date: 30/06/2018

Acceptance date: 02/04/2018

ISSN (electronic): 2196-5471

Publisher: Springer


DOI: 10.1007/s40588-018-0100-3