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Nanoimprinting of biomedical polymers reduces candidal physical adhesion

Lookup NU author(s): Dr Christopher NileORCiD



This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).


© 2018 Elsevier Inc. Management of fungal biofilms represents a significant challenge to healthcare. As a preventive approach, minimizing adhesion between indwelling medical devices and microorganisms would be an important step forward. This study investigated the anti-fouling capacity of engineered nanoscale topographies to the pathogenic yeast Candida albicans. Highly ordered arrays of nano-pit topographies were shown to significantly reduce the physical adherence capacity of C. albicans. This study shows a potential of nanoscale patterns to inhibit and prevent pathogenic biofilm formation on biomedical substrates.

Publication metadata

Author(s): Alalwan H, Nile CJ, Rajendran R, McKerlie R, Reynolds P, Gadegaard N, Ramage G

Publication type: Article

Publication status: Published

Journal: Nanomedicine: Nanotechnology, Biology, and Medicine

Year: 2018

Volume: 14

Issue: 3

Pages: 1045-1049

Print publication date: 01/04/2018

Online publication date: 02/02/2018

Acceptance date: 21/01/2018

Date deposited: 24/02/2020

ISSN (print): 1549-9634

ISSN (electronic): 1549-9642

Publisher: Elsevier Inc.


DOI: 10.1016/j.nano.2018.01.011

PubMed id: 29408656


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