Toggle Main Menu Toggle Search

Open Access padlockePrints

Dentures are a Reservoir for Respiratory Pathogens

Lookup NU author(s): Dr Christopher NileORCiD


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


© 2016 American College of Prosthodontists.Purpose: Recent studies have established a relationship between dental plaque and pulmonary infection, particularly in elderly individuals. Given that approximately one in five adults in the UK currently wears a denture, there remains a gap in our understanding of the direct implications of denture plaque on systemic health. The aim of this study was to undertake a comprehensive evaluation of putative respiratory pathogens residing upon dentures using a targeted quantitative molecular approach. Materials and Methods: One hundred and thirty patients' dentures were sonicated to remove denture plaque biofilm from the surface. DNA was extracted from the samples and was assessed for the presence of respiratory pathogens by qunatitative polymerase chain reaction (qPCR). Ct values were then used to approximate the number of corresponding colony forming equivalents (CFEs) based on standard curves. Results: Of the dentures, 64.6% were colonized by known respiratory pathogens. Six species were identified: Streptococcus aureus, Streptococcus pneumoniae, Pseudomonas aeruginosa, Haemophilus influenzae B, Streptococcus pyogenes, and Moraxella catarrhalis. P. aeruginosa was the most abundant species followed by S. pneumoniae and S. aureus in terms of average CFE and overall proportion of denture plaque. Of the participants, 37% suffered from denture stomatitis; however, there were no significant differences in the prevalence of respiratory pathogens on dentures between healthy and inflamed mouths. Conclusions: Our findings indicate that dentures can act as a reservoir for potential respiratory pathogens in the oral cavity, thus increasing the theoretical risk of developing aspiration pneumonia. Implementation of routine denture hygiene practices could help to reduce the risk of respiratory infection among the elderly population.

Publication metadata

Author(s): O'Donnell LE, Smith K, Williams C, Nile CJ, Lappin DF, Bradshaw D, Lambert M, Robertson DP, Bagg J, Hannah V, Ramage G

Publication type: Article

Publication status: Published

Journal: Journal of Prosthodontics

Year: 2016

Volume: 25

Issue: 2

Pages: 99-104

Print publication date: 01/02/2016

Online publication date: 10/08/2015

Acceptance date: 05/05/2015

ISSN (print): 1059-941X

ISSN (electronic): 1532-849X

Publisher: Blackwell Publishing Inc.


DOI: 10.1111/jopr.12342

PubMed id: 26260391


Altmetrics provided by Altmetric