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The yeast Mig1 transcriptional repressor is dephosphorylated by glucose-dependent and -independent mechanisms

Lookup NU author(s): Dr Adam WollmanORCiD

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Abstract

© FEMS 2017. A yeast Saccharomyces cerevisiae Snf1 kinase, an analog of mammalian AMPK, regulates glucose derepression of genes required for utilization of alternative carbon sources through the transcriptional repressor Mig1. It has been suggested that the Glc7-Reg1 phosphatase dephosphorylates Mig1. Here we report that Mig1 is dephosphorylated by Glc7-Reg1 in an apparently glucose-dependent mechanism but also by a mechanism independent of glucose and Glc7-Reg1. In addition to serine/threonine phosphatases another process including tyrosine phosphorylation seems crucial for Mig1 regulation. Taken together, Mig1 dephosphorylation appears to be controlled in a complex manner, in line with the importance for rapid and sensitive regulation upon altered glucose concentrations in the growth medium.

Publication metadata

Author(s): Shashkova S, Wollman AJM, Leake MC, Hohmann S

Publication type: Letter

Publication status: Published

Journal: FEMS Microbiology Letters

Year: 2017

Volume: 364

Issue: 14

Print publication date: 01/07/2017

Online publication date: 22/06/2017

Acceptance date: 21/06/2017

ISSN (print): 0378-1097

ISSN (electronic): 1574-6968

Publisher: Oxford University Press

URL: https://doi.org/10.1093/femsle/fnx133

DOI: 10.1093/femsle/fnx133

PubMed id: 28854669

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