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Enteric Type Bartholin Gland Adenocarcinoma: An Unusual Variant of a Rare Neoplasm

Lookup NU author(s): Dr Ann Fisher, Dr Yvette DrewORCiD, Dr Rachel O'DonnellORCiD

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Abstract

Copyright © 2020 International Society of Gynecological Pathologists. Vulval cancer is rare. With Bartholin gland carcinomas representing <5% of all vulval carcinomas they present both diagnostic and management challenges. There are a small number of cases in the literature describing Bartholin gland carcinomas with unusual histology which necessitates the need to explore the possibility of metastases from elsewhere. We present a case of a 55-yr-old woman presenting with a vulval lesion within the Bartholin gland. Morphology demonstrated enteric type adenocarcinoma and the immunohistochemistry profile was positive for CK7, CK20, CDX2, CEA, and CA19-9. There was no evidence of an alternative primary cancer and the tumor was excised with negative regional sentinel node assessment. Genotyping showed no detectable mutations in KRAS, BRAF or NRAS suggesting a possible future role for anti-EGFR therapy.

Publication metadata

Author(s): Robinson H, Karpe M, Edidi I, Fisher A, Drew Y, Ralte A, O'Donnell RL

Publication type: Article

Publication status: Published

Journal: International Journal of Gynecological Pathology

Year: 2021

Volume: 40

Issue: 2

Pages: 190-195

Print publication date: 01/03/2021

Online publication date: 23/01/2020

Acceptance date: 02/04/2018

ISSN (print): 0277-1691

ISSN (electronic): 1538-7151

Publisher: Lippincott Williams and Wilkins

URL: https://doi.org/10.1097/PGP.0000000000000667

DOI: 10.1097/PGP.0000000000000667

PubMed id: 31985580

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