Toggle Main Menu Toggle Search

Open Access padlockePrints

Hepatic Lipoprotein Export and Remission of Human Type 2 Diabetes after Weight Loss

Lookup NU author(s): Dr Ahmad Al-Mrabeh, Dr Sviatlana Zhyzhneuskaya, Dr Carl Peters, Alison Barnes, Shaden Melhem, Dr Kieren Hollingsworth, Professor Georg Lietz, Professor John Mathers, Dr Naweed Sattar, Professor Roy Taylor

Downloads


Licence

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).


Abstract

The role of hepatic lipoprotein metabolism in diet-induced remission of type 2 diabetes is currently unclear. Here, we determined the contributions of hepatic VLDL1-triglyceride production rate and VLDL1-palmitic acid content to changes in intra-pancreatic fat and return of first phase insulin response in a subgroup of the Diabetes Remission Clinical Trial. Liver fat, VLDL1-triglyceride production, and intra-pancreatic fat decreased after weight loss and remained normalized after 24 months of remission. First-phase insulin response remained increased only in those maintaining diabetes remission. Compared with those in remission at 24 months, individuals who relapsed after initial remission had a greater rise in the content of VLDL1-triglyceride and VLDL1-palmitic acid, re-accumulated intra-pancreatic fat, and lost first-phase response by 24 months. Thus, we observed temporal relationships between VLDL1-triglyceride production, hepatic palmitic acid flux, intra-pancreatic fat, and β-cell function. Weight-related disordered fat metabolism appears to drive development and reversal of type 2 diabetes.


Publication metadata

Author(s): Al-Mrabeh A, Zhyzhneuskaya SV, Peters C, Barnes AC, Melhem S, Jesuthasan A, Aribasala B, Hollingsworth KG, Lietz G, Mathers JC, Sattar N, Lean MEJ, Taylor R

Publication type: Article

Publication status: Published

Journal: Cell Metabolism

Year: 2020

Volume: 31

Issue: 2

Pages: 233-249

Print publication date: 04/02/2020

Online publication date: 19/12/2019

Acceptance date: 25/11/2019

Date deposited: 20/02/2020

ISSN (print): 1550-4131

ISSN (electronic): 1932-7420

Publisher: Elsevier Inc

URL: https://doi.org/10.1016/j.cmet.2019.11.018

DOI: 10.1016/j.cmet.2019.11.018

PubMed id: 31866441


Altmetrics

Altmetrics provided by Altmetric


Actions

Find at Newcastle University icon    Link to this publication


Share