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Role of phytochemicals as nutraceuticals for cognitive functions affected in ageing

Lookup NU author(s): Emeritus Professor Elaine Perry


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© 2019 Crown Copyright. British Journal of Pharmacology © 2019 British Pharmacological SocietyCognitive decline can occur with normal ageing and in age-related brain disorders, such as mild cognitive impairment and dementia, including Alzheimer's disease, with limited pharmacological therapies available. Other approaches to reduce cognitive decline are urgently needed, and so, the role of dietary interventions or nutraceuticals has received much attention in this respect. In this review, we examine the evidence for dietary plants and their chemical constituents as nutraceuticals, relevant to both cognitive decline in normal ageing and in dementia. Pharmacological (in vitro and in vivo), clinical and epidemiological evidence is assessed for both frequently consumed plants and their dietary forms, including tea, coffee, cocoa (chocolate), red wine, grapes, citrus and other fruits; in addition to plants used less frequently in certain diets and those that cross the blurred boundaries between foods, nutraceuticals and medicinal plants. For the latter, turmeric, saffron, sage, rosemary and lemon balm are examples of those discussed.

Publication metadata

Author(s): Howes M-JR, Perry NSL, Vasquez-Londono C, Perry EK

Publication type: Review

Publication status: Published

Journal: British Journal of Pharmacology

Year: 2020

Volume: 177

Issue: 6

Pages: 1294-1315

Print publication date: 04/03/2020

Online publication date: 25/10/2019

Acceptance date: 03/10/2019

ISSN (print): 0007-1188

ISSN (electronic): 1476-5381

Publisher: John Wiley and Sons Inc.


DOI: 10.1111/bph.14898

PubMed id: 31650528