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Lookup NU author(s): Emeritus Professor Elaine Perry
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© 2019 Crown Copyright. British Journal of Pharmacology © 2019 British Pharmacological SocietyCognitive decline can occur with normal ageing and in age-related brain disorders, such as mild cognitive impairment and dementia, including Alzheimer's disease, with limited pharmacological therapies available. Other approaches to reduce cognitive decline are urgently needed, and so, the role of dietary interventions or nutraceuticals has received much attention in this respect. In this review, we examine the evidence for dietary plants and their chemical constituents as nutraceuticals, relevant to both cognitive decline in normal ageing and in dementia. Pharmacological (in vitro and in vivo), clinical and epidemiological evidence is assessed for both frequently consumed plants and their dietary forms, including tea, coffee, cocoa (chocolate), red wine, grapes, citrus and other fruits; in addition to plants used less frequently in certain diets and those that cross the blurred boundaries between foods, nutraceuticals and medicinal plants. For the latter, turmeric, saffron, sage, rosemary and lemon balm are examples of those discussed.
Author(s): Howes M-JR, Perry NSL, Vasquez-Londono C, Perry EK
Publication type: Review
Publication status: Published
Journal: British Journal of Pharmacology
Year: 2020
Volume: 177
Issue: 6
Pages: 1294-1315
Print publication date: 04/03/2020
Online publication date: 25/10/2019
Acceptance date: 03/10/2019
ISSN (print): 0007-1188
ISSN (electronic): 1476-5381
Publisher: John Wiley and Sons Inc.
URL: https://doi.org/10.1111/bph.14898
DOI: 10.1111/bph.14898
PubMed id: 31650528
