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Smoking status and mortality outcomes following percutaneous coronary intervention

Lookup NU author(s): Professor Azfar Zaman, Dr Mohaned Egred, Dr Alan Bagnall, Dr Jannath Ahmed, Dr Richard Edwards, Dr Rajiv Das

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Abstract

© The European Society of Cardiology 2020.Objective: The aim of this study was to assess the impact of smoking on short (30-day) and intermediate (30-day to 6-month) mortality following percutaneous coronary intervention (PCI). Background: The effect of smoking on mortality post-PCI is lacking in the modern PCI era. Methods: This was a retrospective analysis of prospectively collected data comparing short- and intermediate-term mortality amongst smokers, ex-smokers and non-smokers. Results: The study cohort consisted of 12,656 patients: never-smokers (n = 4288), ex-smokers (n = 4806) and current smokers (n = 3562). The mean age (±standard deviation) was 57 (±11) years in current smokers compared with 67 (±11) in ex-smokers and 67 (±12) in never-smokers; p < 0.0001. PCI was performed for acute coronary syndrome (ACS) in 84.1% of current smokers, 57% of ex-smokers and 62.9% in never-smokers; p < 0.0001. In a logistic regression model, the adjusted odds ratios (95% confidence intervals (CIs)) for 30-day mortality were 1.60 (1.10–2.32) in current smokers and 0.98 (0.70–1.38) in ex-smokers compared with never-smokers. In the Cox proportional hazard model, the adjusted hazard ratios (95% CI) for mortality between 30 days and 6 months were 1.03 (0.65–1.65) in current smokers and 1.19 (0.84–1.67) in ex-smokers compared with never-smokers. Conclusion: This large observational study of non-selected patients demonstrates that ex-smokers and never-smokers are of similar age at first presentation to PCI, and there is no short- or intermediate-term mortality difference between them following PCI. Current smokers undergo PCI at a younger age, more often for ACS, and have higher short-term mortality. These findings underscore the public message on the benefits of smoking cessation and the harmful effects of smoking.


Publication metadata

Author(s): Parasuraman S, Zaman AG, Egred M, Bagnall A, Broadhurst PA, Ahmed J, Edwards R, Das R, Garg D, Purcell I, Noman A

Publication type: Article

Publication status: Published

Journal: European Journal of Preventive Cardiology

Year: 2020

Online publication date: 03/02/2020

Acceptance date: 05/01/2020

ISSN (print): 2047-4873

ISSN (electronic): 2047-4881

Publisher: Sage Publications Inc.

URL: https://doi.org/10.1177/2047487320902325

DOI: 10.1177/2047487320902325

PubMed id: 32013611


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