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Lookup NU author(s): Professor Jordi Diaz ManeraORCiD,
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© 2018 Wiley Periodicals, Inc. Introduction: Particular fibroadipose infiltration patterns have been recently described by muscle imaging in congenital and later onset forms of LMNA-related muscular dystrophies (LMNA-RD). Methods: Scores for fibroadipose infiltration of 23 lower limb muscles in 34 patients with LMNA-RD were collected from heat maps of 2 previous studies. Scoring systems were homogenized. Relationships between muscle infiltration and disease duration and age of onset were modeled with random forests. Results: The pattern of infiltration differs according to disease duration but not to age of disease onset. The muscles whose progression best predicts disease duration were semitendinosus, biceps femoris long head, gluteus medius, and semimembranosus. Discussion: In LMNA-RD, our synthetic analysis of lower limb muscle infiltration did not find major differences between forms with different ages of onset but allowed the identification of muscles with characteristic infiltration during disease progression. Monitoring of these specific muscles by quantitative MRI may provide useful imaging biomarkers in LMNA-RD. Muscle Nerve 58:812–817, 2018.
Author(s): GoMez-Andres D, Diaz-Manera J, Alejaldre A, Pulido-Valdeolivas I, GonzaLez-mera L, Olive M, Vilchez JJ, De Munain AL, Paradas C, Muelas N, SaNchez-MontaNez A, Alonso-Jimenez A, De la banda MGG, Dabaj I, Bonne G, Munell F, Carlier RY, Quijano-Roy S
Publication type: Article
Publication status: Published
Journal: Muscle and Nerve
Print publication date: 01/12/2018
Online publication date: 31/07/2018
Acceptance date: 24/07/2018
ISSN (print): 0148-639X
ISSN (electronic): 1097-4598
Publisher: John Wiley and Sons Inc.
PubMed id: 30066418
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