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Lookup NU author(s): Dr Abhishek Banerjee
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2016 Danielle Feldman et al. Rett Syndrome was long considered to be simply a disorder of postnatal development, with phenotypes that manifest only late in development and into adulthood. A variety of recent evidence demonstrates that the phenotypes of Rett Syndrome are present at the earliest stages of brain development, including developmental stages that define neurogenesis, migration, and patterning in addition to stages of synaptic and circuit development and plasticity. These phenotypes arise from the pleotropic effects of MeCP2, which is expressed very early in neuronal progenitors and continues to be expressed into adulthood. The effects of MeCP2 are mediated by diverse signaling, transcriptional, and epigenetic mechanisms. Attempts to reverse the effects of Rett Syndrome need to take into account the developmental dynamics and temporal impact of MeCP2 loss.
Author(s): Feldman D, Banerjee A, Sur M
Publication type: Review
Publication status: Published
Journal: Neural Plasticity
Year: 2016
Volume: 2016
Online publication date: 31/01/2016
Acceptance date: 31/12/2015
ISSN (print): 2090-5904
ISSN (electronic): 1687-5443
Publisher: Hindawi Limited
URL: https://doi.org/10.1155/2016/6154080
DOI: 10.1155/2016/6154080
PubMed id: 26942018
