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Lookup NU author(s): Dr Abhishek Banerjee
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© 2015 Elsevier Ltd. Presynaptic NMDA receptors (preNMDARs) play pivotal roles in excitatory neurotransmission and synaptic plasticity. They facilitate presynaptic neurotransmitter release and modulate mechanisms controlling synaptic maturation and plasticity during formative periods of brain development. There is an increasing understanding of the roles of preNMDARs in experience-dependent synaptic and circuit-specific computation. In this review we summarize the latest understanding of compartment-specific expression and function of preNMDARs, and how they contribute to synapse-specific and circuit-level information processing. PreNMDARs regulate synapse-specific neurotransmitter release and synaptic plasticity.PreNMDARs often enhance neurotransmission at specific rates of presynaptic neuron firing.The expression of preNMDARs is developmentally regulated and influenced by sensory experience.PreNMDARs are predominantly localized at presynaptic boutons.The NMDAR subunits and downstream signaling cascades associated with preNMDARs are often distinct from postsynaptic NMDARs.Astrocytes regulate preNMDAR-mediated plasticity and neurotransmission.PreNMDAR function is disrupted in several neurological disorders and promises to be an important therapeutic target.
Author(s): Banerjee A, Larsen RS, Philpot BD, Paulsen O
Publication type: Review
Publication status: Published
Journal: Trends in Neurosciences
Year: 2016
Volume: 39
Issue: 1
Pages: 26-39
Print publication date: 01/01/2016
Online publication date: 23/12/2015
Acceptance date: 01/01/1900
ISSN (print): 0166-2236
ISSN (electronic): 1878-108X
Publisher: Elsevier Ltd
URL: https://doi.org/10.1016/j.tins.2015.11.001
DOI: 10.1016/j.tins.2015.11.001
PubMed id: 26726120
