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Lookup NU author(s): Dr Chien-Yi ChangORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2019 The Royal Society of Chemistry.Bacterial quorum sensing has been implicated in a number of pathogenic bacterial processes, such as biofilm formation, making it a crucial target for developing materials with a novel antibiotic mode of action. This paper describes poly(N-isopropyl acrylamide) that has been covalently linked, at multiple chain ends, to homoserine lactone to give a highly branched polymer functionalized with a key messenger molecule implicated in QS. This novel functional material has shown promising anti-QS activity in a Chromobacterium violaceum assay.
Author(s): Shepherd J, Swift T, Chang C-Y, Boyne JR, Rimmer S, Martin WHC
Publication type: Article
Publication status: Published
Journal: Chemical Communications
Online publication date: 29/07/2019
Acceptance date: 29/05/2019
Date deposited: 24/02/2020
ISSN (print): 1359-7345
ISSN (electronic): 1364-548X
Publisher: Royal Society of Chemistry
PubMed id: 31355394
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