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Highly branched poly(N-isopropyl acrylamide) functionalized with an inducer molecule suppresses quorum sensing in Chromobacterium violaceum

Lookup NU author(s): Dr Chien-Yi ChangORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2019 The Royal Society of Chemistry.Bacterial quorum sensing has been implicated in a number of pathogenic bacterial processes, such as biofilm formation, making it a crucial target for developing materials with a novel antibiotic mode of action. This paper describes poly(N-isopropyl acrylamide) that has been covalently linked, at multiple chain ends, to homoserine lactone to give a highly branched polymer functionalized with a key messenger molecule implicated in QS. This novel functional material has shown promising anti-QS activity in a Chromobacterium violaceum assay.

Publication metadata

Author(s): Shepherd J, Swift T, Chang C-Y, Boyne JR, Rimmer S, Martin WHC

Publication type: Article

Publication status: Published

Journal: Chemical Communications

Year: 2019

Volume: 55

Issue: 66

Pages: 9765-9768

Online publication date: 29/07/2019

Acceptance date: 29/05/2019

Date deposited: 24/02/2020

ISSN (print): 1359-7345

ISSN (electronic): 1364-548X

Publisher: Royal Society of Chemistry


DOI: 10.1039/C9CC02524C

PubMed id: 31355394


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Funder referenceFunder name
MRC/DBT MR/N501888/2
Wellcome Trust 099800/C/12/Z