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Lookup NU author(s): Professor Tracy Palmer FRS FRSE FMedSciORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2020 The Authors. Molecular Microbiology published by John Wiley & Sons Ltd. The twin-arginine protein transport (Tat pathway) is found in prokaryotes and plant organelles and transports folded proteins across membranes. Targeting of substrates to the Tat system is mediated by the presence of an N-terminal signal sequence containing a highly conserved twin-arginine motif. The Tat machinery comprises membrane proteins from the TatA and TatC families. Assembly of the Tat translocon is dynamic and is triggered by the interaction of a Tat substrate with the Tat receptor complex. This review will summarise recent advances in our understanding of Tat transport, focusing in particular on the roles played by Tat signal peptides in protein targeting and translocation.
Author(s): Palmer T, Stansfeld PJ
Publication type: Review
Publication status: Published
Journal: Molecular Microbiology
Year: 2020
Volume: 113
Issue: 5
Pages: 861-871
Print publication date: 01/05/2020
Online publication date: 23/01/2020
Acceptance date: 12/01/2020
ISSN (print): 0950-382X
ISSN (electronic): 1365-2958
Publisher: Blackwell Publishing Ltd
URL: https://doi.org/10.1111/mmi.14461
DOI: 10.1111/mmi.14461
PubMed id: 31971282
