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Targeting of proteins to the twin-arginine translocation pathway

Lookup NU author(s): Professor Tracy Palmer FRS FRSE FMedSciORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2020 The Authors. Molecular Microbiology published by John Wiley & Sons Ltd. The twin-arginine protein transport (Tat pathway) is found in prokaryotes and plant organelles and transports folded proteins across membranes. Targeting of substrates to the Tat system is mediated by the presence of an N-terminal signal sequence containing a highly conserved twin-arginine motif. The Tat machinery comprises membrane proteins from the TatA and TatC families. Assembly of the Tat translocon is dynamic and is triggered by the interaction of a Tat substrate with the Tat receptor complex. This review will summarise recent advances in our understanding of Tat transport, focusing in particular on the roles played by Tat signal peptides in protein targeting and translocation.

Publication metadata

Author(s): Palmer T, Stansfeld PJ

Publication type: Review

Publication status: Published

Journal: Molecular Microbiology

Year: 2020

Volume: 113

Issue: 5

Pages: 861-871

Print publication date: 01/05/2020

Online publication date: 23/01/2020

Acceptance date: 12/01/2020

ISSN (print): 0950-382X

ISSN (electronic): 1365-2958

Publisher: Blackwell Publishing Ltd


DOI: 10.1111/mmi.14461

PubMed id: 31971282