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Protein-based Fluorescent Metal Nanoclusters for Small Molecular Drug Screening

Lookup NU author(s): Professor Yen Nee Tan

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Abstract

A facile drug screening method based on synthesis of fluorescent gold nanoclusters inside albumin proteins loaded with small molecular drugs and comparing the relative fluorescence intensities of the resultant gold nanoclusters has been developed and successfully applied for the quantitative measurement of drug–protein binding constants.

Publication metadata

Author(s): Yu Y, New SY, Xie J, Su X, Tan YN

Publication type: Article

Publication status: Published

Journal: Chemical Communications

Year: 2014

Volume: 50

Pages: 13805-13808

Print publication date: 18/11/2014

Online publication date: 17/09/2014

Acceptance date: 17/09/2014

ISSN (print): 1359-7345

ISSN (electronic): 1364-548X

Publisher: Royal Society of Chemistry

URL: https://doi.org/10.1039/c4cc06914e

DOI: 10.1039/c4cc06914e

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