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Whole genome sequence of dermacoccus abyssi MT1.1 isolated from the challenger deep of the mariana trench reveals phenazine biosynthesis locus and environmental adaptation factors

Lookup NU author(s): Dr Imen Nouioui, Professor Michael Goodfellow



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( abyssi strain MT1.1T is a piezotolerant actinobacterium that was isolated from Mariana Trench sediment collected at a depth of 10898 m. The organism was found to produce ten dermacozines (A-J) that belonged to a new phenazine family and which displayed various biological activities such as radical scavenging and cytotoxicity. Here, we report on the isolation and identification of a new dermacozine compound, dermacozine M, the chemical structure of which was determined using 1D and 2D-NMR, and high resolution MS. A whole genome sequence of the strain contained six secondary metabolite-biosynthetic gene clusters (BGCs), including one responsible for the biosynthesis of a family of phenazine compounds. A pathway leading to the biosynthesis of dermacozines is proposed. Bioinformatic analyses of key stress-related genes provide an insight into how the organism adapted to the environmental conditions that prevail in the deep-sea.

Publication metadata

Author(s): Abdel-Mageed WM, Juhasz B, Lehri B, Alqahtani AS, Nouioui I, Pech-Puch D, Tabudravu JN, Goodfellow M, Rodriguez J, Jaspars M, Karlyshev AV

Publication type: Article

Publication status: Published

Journal: Marine Drugs

Year: 2020

Volume: 18

Issue: 3

Online publication date: 25/02/2020

Acceptance date: 21/02/2020

Date deposited: 30/03/2020

ISSN (print): 1660-3397

ISSN (electronic): 1660-3397

Publisher: MDPI AG


DOI: 10.3390/md18030131

PubMed id: 32106586


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