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Lookup NU author(s): Dr Imen Nouioui, Professor Michael Goodfellow
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).Dermacoccus abyssi strain MT1.1T is a piezotolerant actinobacterium that was isolated from Mariana Trench sediment collected at a depth of 10898 m. The organism was found to produce ten dermacozines (A-J) that belonged to a new phenazine family and which displayed various biological activities such as radical scavenging and cytotoxicity. Here, we report on the isolation and identification of a new dermacozine compound, dermacozine M, the chemical structure of which was determined using 1D and 2D-NMR, and high resolution MS. A whole genome sequence of the strain contained six secondary metabolite-biosynthetic gene clusters (BGCs), including one responsible for the biosynthesis of a family of phenazine compounds. A pathway leading to the biosynthesis of dermacozines is proposed. Bioinformatic analyses of key stress-related genes provide an insight into how the organism adapted to the environmental conditions that prevail in the deep-sea.
Author(s): Abdel-Mageed WM, Juhasz B, Lehri B, Alqahtani AS, Nouioui I, Pech-Puch D, Tabudravu JN, Goodfellow M, Rodriguez J, Jaspars M, Karlyshev AV
Publication type: Article
Publication status: Published
Journal: Marine Drugs
Year: 2020
Volume: 18
Issue: 3
Online publication date: 25/02/2020
Acceptance date: 21/02/2020
Date deposited: 30/03/2020
ISSN (print): 1660-3397
ISSN (electronic): 1660-3397
Publisher: MDPI AG
URL: https://doi.org/10.3390/md18030131
DOI: 10.3390/md18030131
PubMed id: 32106586
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