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Oscillatory flow bioreactor (OFB) applied in enzymatic hydrolysis at high solid loadings

Lookup NU author(s): Dr Judith Buchmaier, Professor Anh Phan, Professor Adam Harvey



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2020 Assoc. of Chemists and Chemical Engineers of Croatia. All rights reserved. Within this study, an enzymatic hydrolysis process using α-cellulosic feedstock was performed in a specially designed plug-flow reactor, referred to as an Oscillatory Flow Bioreactor (OFB). The aims of this approach were to achieve intensification in terms of realising a more energy- and resource-efficient enzymatic hydrolysis, as well as to set the basis for continuous processes in such a reactor. The OFB performance was evaluated for high solid loadings of up to 15 %, and compared to the performance of a Stirred Tank Reactor (STR). Experimental results of the OFB operating at an oscillation frequency of 2 Hz and an oscillation amplitude of 10 mm exhibit better conversion efficiencies (+ 6.7 %) than the STR after 24 h, while requiring only 7 % of the STR power density (W m-3). Therefore, the OFB enables efficient, uniform mixing at lower power densities than STRs for applications with high solid loadings.

Publication metadata

Author(s): Buchmaier J, Brunner C, Griesbacher U, Phan AN, Harvey AP, Krishna Gudiminchi R, Nidetzky B, Muster B

Publication type: Article

Publication status: Published

Journal: Chemical and Biochemical Engineering Quarterly

Year: 2019

Volume: 33

Issue: 4

Pages: 459-470

Print publication date: 31/12/2019

Acceptance date: 25/11/2019

Date deposited: 02/04/2020

ISSN (print): 0352-9568

ISSN (electronic): 1846-5153

Publisher: Association of Chemists and Chemical Engineers of Croatia


DOI: 10.15255/CABEQ.2018.1553


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