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Long-term strength and functional status in inclusion body myositis and identification of trajectory subgroups

Lookup NU author(s): Dr James Miller

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

© 2020 The Authors. Muscle & Nerve published by Wiley Periodicals, Inc. Introduction: Objective information on longitudinal disease progression in inclusion body myositis (IBM) is lacking. Methods: Longitudinal dynamometry and functional status data were collated from a cohort of IBM patients. Annual change was calculated by means of linear modeling. Trajectories of change in grip, knee extension, IBM Functional Rating Scale (IBM-FRS) and Neuromuscular Symptom Score (NSS) were identified by means of latent growth mixture modeling. Results: Data were collated from 75 IBM patients (348 person-years follow-up). Annual strength loss was greatest for pinch (−10%) and knee extension (−4%). Functional deterioration was greatest for males. Three distinct trajectory groups were identified. Rapid deterioration trajectory for grip strength was associated with younger diagnosis age. Rapid deterioration for knee extension strength was associated with older age of diagnosis. Discussion: This study has quantified strength change in IBM and identified distinct trajectory groups, which will aid prognostication and stratification for inclusion into future clinical trials.


Publication metadata

Author(s): Oldroyd AGS, Lilleker JB, Williams J, Chinoy H, Miller JAL

Publication type: Article

Publication status: Published

Journal: Muscle and Nerve

Year: 2020

Volume: 62

Issue: 1

Pages: 76-82

Print publication date: 01/07/2020

Online publication date: 05/03/2020

Acceptance date: 01/03/2020

Date deposited: 25/06/2021

ISSN (print): 0148-639X

ISSN (electronic): 1097-4598

Publisher: John Wiley and Sons Inc.

URL: https://doi.org/10.1002/mus.26859

DOI: 10.1002/mus.26859

PubMed id: 32134516


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Funding

Funder referenceFunder name
21993
MR/N003322/1

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