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Lookup NU author(s): Dr James Miller
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2020 The Authors. Muscle & Nerve published by Wiley Periodicals, Inc. Introduction: Objective information on longitudinal disease progression in inclusion body myositis (IBM) is lacking. Methods: Longitudinal dynamometry and functional status data were collated from a cohort of IBM patients. Annual change was calculated by means of linear modeling. Trajectories of change in grip, knee extension, IBM Functional Rating Scale (IBM-FRS) and Neuromuscular Symptom Score (NSS) were identified by means of latent growth mixture modeling. Results: Data were collated from 75 IBM patients (348 person-years follow-up). Annual strength loss was greatest for pinch (−10%) and knee extension (−4%). Functional deterioration was greatest for males. Three distinct trajectory groups were identified. Rapid deterioration trajectory for grip strength was associated with younger diagnosis age. Rapid deterioration for knee extension strength was associated with older age of diagnosis. Discussion: This study has quantified strength change in IBM and identified distinct trajectory groups, which will aid prognostication and stratification for inclusion into future clinical trials.
Author(s): Oldroyd AGS, Lilleker JB, Williams J, Chinoy H, Miller JAL
Publication type: Article
Publication status: Published
Journal: Muscle and Nerve
Year: 2020
Volume: 62
Issue: 1
Pages: 76-82
Print publication date: 01/07/2020
Online publication date: 05/03/2020
Acceptance date: 01/03/2020
Date deposited: 25/06/2021
ISSN (print): 0148-639X
ISSN (electronic): 1097-4598
Publisher: John Wiley and Sons Inc.
URL: https://doi.org/10.1002/mus.26859
DOI: 10.1002/mus.26859
PubMed id: 32134516
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