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Lookup NU author(s): Jonathan Tellechea Luzardo, Dr Charles WinterhalterORCiD, Dr Paweł Widera, Dr Jurek Kozyra, Professor Natalio KrasnogorORCiD
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
As DNA sequencing and synthesis become cheaper and more easily accessible, the scale and complexity of biological engineering projects is set to grow. Yet, although there is an accelerating convergence between biotechnology and digital technology, a deficit in software and laboratory techniques diminishes the ability to make biotechnology more agile, reproducible, and transparent while, at the same time, limiting the security and safety of synthetic biology constructs. To partially address some of these problems, this paper presents an approach for physically linking engineered cells to their digital footprint-we called it digital twinning. This enables the tracking of the entire engineering history of a cell line in a specialized version control system for collaborative strain engineering via simple barcoding protocols.
Author(s): Tellechea-Luzardo J, Winterhalter C, Widera P, Kozyra J, de Lorenzo V, Krasnogor N
Publication type: Article
Publication status: Published
Journal: ACS synthetic biology
Year: 2020
Volume: 9
Issue: 3
Pages: 536-545
Print publication date: 20/03/2020
Online publication date: 20/02/2020
Acceptance date: 01/10/2019
Date deposited: 23/11/2020
ISSN (electronic): 2161-5063
Publisher: American Chemical Society
URL: https://doi.org/10.1021/acssynbio.9b00400
DOI: 10.1021/acssynbio.9b00400
PubMed id: 32078768
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