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The developing immune network in human prenatal skin

Lookup NU author(s): Dr Rachel Botting, Professor Muzlifah Haniffa



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2020 The Authors. Immunology published by John Wiley & Sons Ltd. Establishment of a well-functioning immune network in skin is crucial for its barrier function. This begins in utero alongside the structural differentiation and maturation of skin, and continues to expand and diversify across the human lifespan. The microenvironment of the developing human skin supports immune cell differentiation and has an overall anti-inflammatory profile. Immunologically inert and skewed immune populations found in developing human skin promote wound healing, and as such may play a crucial role in the structural changes occurring during skin development.

Publication metadata

Author(s): Botting RA, Haniffa M

Publication type: Review

Publication status: Published

Journal: Immunology

Year: 2020

Volume: 160

Issue: 2

Pages: 149-156

Print publication date: 01/06/2020

Online publication date: 16/03/2020

Acceptance date: 10/03/2020

ISSN (print): 0019-2805

ISSN (electronic): 1365-2567

Publisher: Blackwell Publishing Ltd


DOI: 10.1111/imm.13192

PubMed id: 32173857