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Investigating brain network changes and their association with cognitive recovery after Traumatic Brain Injury: a longitudinal analysis

Lookup NU author(s): Nadia Moreira da Silva, Christopher Cowie, Professor Andrew Blamire, Dr Rob Forsyth, Dr Peter Taylor

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

Traumatic brain injury (TBI) can result in acute cognitive deficits and diffuse axonal injury reflected in white matter brainnetwork alterations which may, or may, not later recover.Our objective is to first characterize the ways in which brain networks change after TBI and second, investigate if those changes are associated with recovery of cognitive deficits. We aim to make initial progress in discerning the relationships between brain network changes, and their (dys)functional correlates.We analyse longitudinally acquired MRI from 23 TBI patients (two time points: 6 days, 12 months post injury) and cross-sectional data from 28 controls to construct white matter brain networks. Cognitive assessment was also performed. Graph theory and regression analysis were applied to identify changed brain network metrics after injury that are associated with subsequent improvements in cognitive function.Sixteen brain network metrics were found to be discriminative of different post-injury phases. Eleven of those explain 90% (adjusted-R2) of the variability observed in cognitive recovery following TBI. Brain network metrics which had a high contribution to the explained variance were found in frontal and temporal cortex, additional to the anterior cingulate cortex.Our preliminary study suggests that network reorganization may be related to recovery of impaired cognitive function in the first year after a TBI


Publication metadata

Author(s): da Silva NM, Cowie C, Blamire AM, Forsyth R, Taylor PN

Publication type: Article

Publication status: Published

Journal: Frontiers Neurology

Year: 2020

Volume: 11

Online publication date: 09/06/2020

Acceptance date: 14/04/2020

Date deposited: 09/06/2020

ISSN (electronic): 1664-2295

Publisher: Frontiers

URL: https://doi.org/10.3389/fneur.2020.00369

DOI: 10.3389/fneur.2020.00369


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