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Dietary intervention in pregnant women with gestational diabetes; protocol for the digest randomised controlled trial

Lookup NU author(s): Professor Roy Taylor

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

© 2020 by the authors. Licensee MDPI, Basel, Switzerland.Gestational diabetes mellitus (GDM) annually affects 35,000 pregnancies in the United Kingdom, causing suboptimal health outcomes to the mother and child. Obesity and excessive gestational weight gain are risk factors for GDM. The Institute of Medicine recommends weight targets for women that are overweight and obese, however, there are no clear guidelines for women with GDM. Observational data suggest that modest weight loss (0.6–2 kg) after 28 weeks may reduce risk of caesarean section, large-for-gestational-age (LGA), and maternal postnatal glycaemia. This protocol for a multicentre randomised double-blind controlled trial aims to identify if a fully controlled reduced energy diet in GDM pregnancy improves infant birthweight and reduces maternal weight gain (primary outcomes). A total of 500 women with GDM (National Institute of Health and Care Excellence (NICE) 2015 criteria) and body mass index (BMI) ≥25 kg/m2 will be randomised to receive a standard (2000 kcal/day) or reduced energy (1200 kcal/day) diet box containing all meals and snacks from 28 weeks to delivery. Women and caregivers will be blinded to the allocations. Food diaries, continuous glucose monitoring, and anthropometry will measure dietary compliance, glucose levels, and weight changes. Women will receive standard antenatal GDM management (insulin/metformin) according to NICE guidelines. The secondary endpoints include caesarean section rates, LGA, and maternal postnatal glucose concentrations.

Publication metadata

Author(s): Kusinski LC, Murphy HR, Rolfe EDL, Rennie KL, Griep LMO, Hughes D, Taylor R, Meek CL

Publication type: Article

Publication status: Published

Journal: Nutrients

Year: 2020

Volume: 12

Issue: 4

Online publication date: 22/04/2020

Acceptance date: 16/04/2020

Date deposited: 04/05/2020

ISSN (print): 2072-6643

ISSN (electronic): 2072-6643

Publisher: MDPI

URL: https://doi.org/10.3390/nu12041165

DOI: 10.3390/nu12041165

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