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Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly

Lookup NU author(s): Dr Sergey MelnikovORCiD


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© 2015 Nature America, Inc. All rights reserved.We report crystal structures of the Thermus thermophilus ribosome at 2.3- to 2.5-Å resolution, which have enabled modeling of rRNA modifications. The structures reveal contacts of modified nucleotides with mRNA and tRNAs or protein pY, and contacts within the ribosome interior stabilizing the functional fold of rRNA. Our work provides a resource to explore the roles of rRNA modifications and yields a more comprehensive atomic model of a bacterial ribosome.

Publication metadata

Author(s): Polikanov YS, Melnikov SV, Soll D, Steitz TA

Publication type: Article

Publication status: Published

Journal: Nature Structural and Molecular Biology

Year: 2015

Volume: 22

Issue: 4

Pages: 342-344

Print publication date: 01/04/2015

Online publication date: 16/03/2015

Acceptance date: 17/02/2015

ISSN (print): 1545-9993

ISSN (electronic): 1545-9985

Publisher: Nature Publishing Group


DOI: 10.1038/nsmb.2992

PubMed id: 25775268


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