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Insights into the origin of the nuclear localization signals in conserved ribosomal proteins

Lookup NU author(s): Dr Sergey MelnikovORCiD

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

© 2015 Macmillan Publishers Limited. All rights reserved.Eukaryotic ribosomal proteins, unlike their bacterial homologues, possess nuclear localization signals (NLSs) to enter the cell nucleus during ribosome assembly. Here we provide a comprehensive comparison of bacterial and eukaryotic ribosomes to show that NLSs appear in conserved ribosomal proteins via remodelling of their RNA-binding domains. This finding enabled us to identify previously unknown NLSs in ribosomal proteins from humans, and suggests that, apart from promoting protein transport, NLSs may facilitate folding of ribosomal RNA.

Publication metadata

Author(s): Melnikov S, Ben-Shem A, Yusupova G, Yusupov M

Publication type: Article

Publication status: Published

Journal: Nature Communications

Year: 2015

Volume: 6

Online publication date: 11/06/2015

Acceptance date: 30/04/2015

Date deposited: 27/05/2020

ISSN (electronic): 2041-1723

Publisher: Nature Publishing Group

URL: https://doi.org/10.1038/ncomms8382

DOI: 10.1038/ncomms8382

PubMed id: 26066547

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