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Lookup NU author(s): Dr Sergey MelnikovORCiD
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© 2016Eukaryotic translation initiation factor eIF5A promotes protein synthesis by resolving polyproline-induced ribosomal stalling. Here, we report a 3.25-Å resolution crystal structure of eIF5A bound to the yeast 80S ribosome. The structure reveals a previously unseen conformation of an eIF5A–ribosome complex and highlights a possible functional link between conformational changes of the ribosome during protein synthesis and the eIF5A–ribosome association.
Author(s): Melnikov S, Mailliot J, Shin B-S, Rigger L, Yusupova G, Micura R, Dever TE, Yusupov M
Publication type: Article
Publication status: Published
Journal: Journal of Molecular Biology
Print publication date: 11/09/2016
Online publication date: 16/05/2016
Acceptance date: 07/05/2016
ISSN (print): 0022-2836
ISSN (electronic): 1089-8638
Publisher: Academic Press
PubMed id: 27196944
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