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Lookup NU author(s): Grace Mallett,
Dr Shoba Amarnath
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© 2020, Springer Science+Business Media, LLC, part of Springer Nature.Innate lymphoid cells (ILCs) are important for both tissue immunity and tissue homeostasis. They are classified into three groups: Group 1 ILCs include NK cells, which are important in eliciting immunity against intracellular pathogens; group 2 ILCs protect against parasitic helminths; and group 3 ILCs protect against extracellular pathogens. The role of ILCs in cancer immunity remains unclear. In this chapter, we discuss methods for isolating and characterizing tumor-infiltrating ILC subsets within the tumor microenvironment in an experimental murine model of B16 melanoma. The chapter also highlights the expression of PD-1 on the various ILC subsets within the tumor microenvironment.
Author(s): Mallett G, Patterson W, Payne M, Amarnath S
Publication type: Book Chapter
Publication status: Published
Book Title: Methods in Molecular Biology
Online publication date: 09/03/2020
Acceptance date: 02/04/2018
Publisher: Humana Press Inc.
Place Published: New York
PubMed id: 32147794
Library holdings: Search Newcastle University Library for this item