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A single day of excessive dietary fat intake reduces whole-body insulin sensitivity: The metabolic consequence of binge eating

Lookup NU author(s): Dr Carl Hulston

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

© 2017 by the authors.Consuming excessive amounts of energy as dietary fat for several days or weeks can impair glycemic control and reduce insulin sensitivity in healthy adults. However, individuals who demonstrate binge eating behavior overconsume for much shorter periods of time; the metabolic consequences of such behavior remain unknown. The aim of this study was to determine the effect of a single day of high-fat overfeeding on whole-body insulin sensitivity. Fifteen young, healthy adults underwent an oral glucose tolerance test before and after consuming a high-fat (68% of total energy), high-energy (78% greater than daily requirements) diet for one day. Fasting and postprandial plasma concentrations of glucose, insulin, non-esterified fatty acids, and triglyceride were measured and the Matsuda insulin sensitivity index was calculated. One day of high-fat overfeeding increased postprandial glucose area under the curve (AUC) by 17.1% (p < 0.0001) and insulin AUC by 16.4% (p = 0.007). Whole-body insulin sensitivity decreased by 28% (p = 0.001). In conclusion, a single day of high-fat, overfeeding impaired whole-body insulin sensitivity in young, healthy adults. This highlights the rapidity with which excessive consumption of calories through high-fat food can impair glucose metabolism, and suggests that acute binge eating may have immediate metabolic health consequences for the individual.


Publication metadata

Author(s): Parry SA, Woods RM, Hodson L, Hulston CJ

Publication type: Article

Publication status: Published

Journal: Nutrients

Year: 2017

Volume: 9

Issue: 8

Online publication date: 29/07/2017

Acceptance date: 26/07/2017

Date deposited: 11/06/2020

ISSN (electronic): 2072-6643

Publisher: MDPI AG

URL: https://doi.org/10.3390/nu9080818

DOI: 10.3390/nu9080818

PubMed id: 28758920


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