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The clinicopathological and gene expression patterns associated with ulceration of primary melanoma

Lookup NU author(s): Dr Jérémie Nsengimana


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© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.Ulceration of primary melanomas is associated with poor prognosis yet is reported to predict benefit from adjuvant interferon. To better understand the biological processes involved, clinicopathological factors associated with ulceration were determined in 1804 patients. From this cohort, 348 primary tumor blocks were sampled to generate gene expression data using a 502-gene cancer panel and 195 blocks were used for immunohistochemistry to detect macrophage infiltration and vessel density. Gene expression results were validated using a whole genome array in two independent sample sets. Ulceration of primary melanomas was associated with more proliferative tumors, tumor vessel invasion, and increased microvessel density. Infiltration of tumors with greater number of macrophages and gene expression pathways associated with wound healing and up-regulation of pro-inflammatory cytokines suggests that ulceration is associated with tumor-related inflammation. The relative benefit from interferon reported in patients with ulcerated tumors may reflect modification of signaling pathways involved in inflammation.

Publication metadata

Author(s): Jewell R, Elliott F, Laye J, Nsengimana J, Davies J, Walker C, Conway C, Mitra A, Harland M, Cook MG, Boon A, Storr S, Safuan S, Martin SG, Jirstrom K, Olsson H, Ingvar C, Lauss M, Bishop T, Jonsson G, Newton-Bishop J

Publication type: Article

Publication status: Published

Journal: Pigment Cell and Melanoma Research

Year: 2015

Volume: 28

Issue: 1

Pages: 94-104

Print publication date: 01/01/2015

Online publication date: 15/09/2014

Acceptance date: 08/09/2014

ISSN (print): 1755-1471

ISSN (electronic): 1755-148X

Publisher: Blackwell Publishing Ltd


DOI: 10.1111/pcmr.12315

PubMed id: 25220403


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