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Interleukin-6 is a negative regulator of hepatic glucose production in the isolated rat liver

Lookup NU author(s): Dr Deb DulsonORCiD


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© 2015 Taylor and Francis.The mechanism underlying the increased rate of endogenous glucose production from the liver during exercise remains unknown. The cytokine interleukin-6 (IL-6) is known to be released during exercise and is thought that either IL-6 directly or via a "contraction factor" stimulates the release of stored glucose from the liver. Here we show that IL-6 does not directly increase hepatic glucose output (HGO). Moreover, IL-6 infused at the same time as glucagon caused a significant reduction in HGO. IL-6 infused with epinephrine caused no synergenic increase in HGO. To test if an unknown "contraction factor" was needed along with IL-6 to increase HGO, we used human fasted and exercised plasma perfused with or without IL-6 in our isolated liver system. We found that exercised plasma increased HGO, as expected, but when infused with IL-6, reductions in HGO were found. Our results provide evidence that IL-6 works as a negative regulator of HGO.

Publication metadata

Author(s): Dent JR, Chowdhury MKH, Tchijov S, Dulson D, Smith G

Publication type: Article

Publication status: Published

Journal: Archives of Physiology and Biochemistry

Year: 2016

Volume: 122

Issue: 2

Pages: 103-109

Print publication date: 14/03/2016

Online publication date: 24/02/2016

Acceptance date: 21/01/2016

ISSN (print): 1381-3455

ISSN (electronic): 1744-4160

Publisher: Taylor and Francis Ltd


DOI: 10.3109/13813455.2016.1146773

PubMed id: 26808480


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