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Lookup NU author(s): Dr Deb DulsonORCiD
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© 2015 Taylor and Francis.The mechanism underlying the increased rate of endogenous glucose production from the liver during exercise remains unknown. The cytokine interleukin-6 (IL-6) is known to be released during exercise and is thought that either IL-6 directly or via a "contraction factor" stimulates the release of stored glucose from the liver. Here we show that IL-6 does not directly increase hepatic glucose output (HGO). Moreover, IL-6 infused at the same time as glucagon caused a significant reduction in HGO. IL-6 infused with epinephrine caused no synergenic increase in HGO. To test if an unknown "contraction factor" was needed along with IL-6 to increase HGO, we used human fasted and exercised plasma perfused with or without IL-6 in our isolated liver system. We found that exercised plasma increased HGO, as expected, but when infused with IL-6, reductions in HGO were found. Our results provide evidence that IL-6 works as a negative regulator of HGO.
Author(s): Dent JR, Chowdhury MKH, Tchijov S, Dulson D, Smith G
Publication type: Article
Publication status: Published
Journal: Archives of Physiology and Biochemistry
Year: 2016
Volume: 122
Issue: 2
Pages: 103-109
Print publication date: 14/03/2016
Online publication date: 24/02/2016
Acceptance date: 21/01/2016
ISSN (print): 1381-3455
ISSN (electronic): 1744-4160
Publisher: Taylor and Francis Ltd
URL: https://doi.org/10.3109/13813455.2016.1146773
DOI: 10.3109/13813455.2016.1146773
PubMed id: 26808480
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