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Effect of a high and low dose of caffeine on human lymphocyte activation in response to antigen stimulation

Lookup NU author(s): Dr Deb DulsonORCiD


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© 2016, National Research Council of Canada. All rights reserved.This study investigated the effect of caffeine on antigen-stimulated lymphocyte activation. Six males rested for 3.5 h after ingesting 0 (PLA), 2, or 6 (6CAF) mg·kg−1 body mass of caffeine. The number of antigen-stimulated NK CD69+ cells increased in 6CAF at 1 h compared with PLA (P = 0.021). Caffeine did not influence the number of antigen-stimulated CD69+ T cells or the geometric mean fluorescence intensity expression of CD69 on antigen-stimulated lymphocytes, suggesting caffeine has little effect on antigen-stimulated lymphocyte activation.

Publication metadata

Author(s): Dulson DK, Bishop NC

Publication type: Article

Publication status: Published

Journal: Applied Physiology, Nutrition and Metabolism

Year: 2016

Volume: 41

Issue: 2

Pages: 224-227

Print publication date: 01/02/2016

Online publication date: 29/10/2015

Acceptance date: 24/10/2015

ISSN (print): 1715-5312

ISSN (electronic): 1715-5320

Publisher: National Research Council of Canada


DOI: 10.1139/apnm-2015-0456

PubMed id: 26789095


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