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Lookup NU author(s): Dr Rob Forsyth
This is the authors' accepted manuscript of an article that has been published in its final definitive form by Elsevier BV, 2020.
For re-use rights please refer to the publisher's terms and conditions.
Objective: To assess the effect of anti-CD20 B-cell depletion with rituximab (RTX) on relapse rates in myelin oligodendrocyte glycoprotein antibody-associated disorder (MOGAD). Methods: Retrospective review of RTX-treated MOGAD patients from 29 centres in 13 countries. The primary outcome measure was change in relapse rate after starting rituximab (Poisson regression model). Results: Data on 121 patients were analysed, including 30 (24.8%) children. Twenty/121 (16.5%) were treated after one attack, of whom 14/20 (70.0%) remained relapse-free after median (IQR) 11.2 (6.3-14.1) months. The remainder (101/121, 83.5%) were treated after two or more attacks, of whom 53/101 (52.5%) remained relapse-free after median 12.1 (6.3-24.9) months. In this ‘relapsing group’, relapse rate declined by 37% (95%CI=19-52%, p<0.001) overall, 63% (95%CI=35-79%, p=0.001) when RTX was used first line (n=47), and 26% (95%CI=2-44%, p=0.038) when used after other steroid-sparing immunotherapies (n=54). Predicted 2-year relapse-free survival was 55% for first-line RTX therapy, and 18% for second-/third-line therapy. Circulating CD19 + B-cells were suppressed to <1% of total circulating lymphocyte population at the time of 45/57 (78.9%) relapses. Conclusion: RTX reduced relapse rates in MOGAD. However, many patients continued to relapse despite apparent B-cell depletion. Prospective controlled studies are needed to validate these results.
Author(s): Whittam DH, Cobo-Calvo A, Lopez-Chiriboga AS, Pardo S, Gornall M, Cicconi S, Brandt A, Berek K, Berger T, Jelcic I, Gombolay A, Oliveira LM, Callegaro D, Kaneko K, Misu T, Capobianco M, Gibbons E, Karthikeayan V, Brochet B, Audoin B, Mathey G, Laplaud D, Thouvenot E, Cohen M, Tourbah A, Maillart E, Ciron K, Deschamps R, Biotti D, Rostasy K, Neuteboom R, Hemingway C, Forsyth R, Matiello M, Webb S, Hunt D, Murray K, Hacohen Y, Lim M, Leite MI, Palace J, Solomon T, Lutterotti A, Fujihara K, Nakshima I, Bennett JL, Pandit L, Chitnis T, Weinshenker BG, Wildemann B, Sato DK, Kim S-H, Huda S, Kim HJ, Reindl M, Levy M, Jarius S, Tenembaum S, Friedemann P, Pittock S, Marignier R, Jacob A
Publication type: Article
Publication status: Published
Journal: Multiple Sclerosis and Related Disorders
Print publication date: 01/09/2020
Online publication date: 02/06/2020
Acceptance date: 02/06/2020
Date deposited: 11/06/2020
ISSN (print): 2211-0348
ISSN (electronic): 2211-0356
Publisher: Elsevier BV
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