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Moving Toward Precision Medicine in Psoriasis and Psoriatic Arthritis

Lookup NU author(s): Professor Nick ReynoldsORCiD

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Abstract

Current management approaches for the treatment of psoriasis and psoriatic arthritis (PsA) are imprecise and depend largely on clinical assessment. A more precise approach, which takes into account an individual patient's variations in genes, proteins, environment, and lifestyle, is beginning to receive attention with the most advanced progress seen in the treatment of cancer. Herein, the methodological approaches required for this precision medicine approach to be adopted in psoriatic disease, as well as their advantages, are reviewed. In addition, advances that are being made to address areas of unmet need in PsA, notably the use of proteomic approaches, are presented with suggestions that combine genetic and protein data (proteogenomics). Finally, progress that is being made in 2 large-scale, multipartner studies focused on the development of a precision medicine approach to the treatment of skin psoriasis is presented and discussed.

Publication metadata

Author(s): Ritchlin CT, Pennington SR, Reynolds NJ, FitzGerald O

Publication type: Article

Publication status: Published

Journal: Journal of Rheumatology

Year: 2020

Volume: 96

Issue: Supplement

Pages: 19-24

Print publication date: 01/06/2020

Online publication date: 01/06/2020

Acceptance date: 02/04/2018

ISSN (print): 0380-0903

ISSN (electronic): 1499-2752

Publisher: The Journal of Rheumatology Publishing Co. Ltd

URL: https://doi.org/10.3899/jrheum.200122

DOI: 10.3899/jrheum.200122

PubMed id: 32482763

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