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Lookup NU author(s): Professor Nick Reynolds
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Current management approaches for the treatment of psoriasis and psoriatic arthritis (PsA) are imprecise and depend largely on clinical assessment. A more precise approach, which takes into account an individual patient's variations in genes, proteins, environment, and lifestyle, is beginning to receive attention with the most advanced progress seen in the treatment of cancer. Herein, the methodological approaches required for this precision medicine approach to be adopted in psoriatic disease, as well as their advantages, are reviewed. In addition, advances that are being made to address areas of unmet need in PsA, notably the use of proteomic approaches, are presented with suggestions that combine genetic and protein data (proteogenomics). Finally, progress that is being made in 2 large-scale, multipartner studies focused on the development of a precision medicine approach to the treatment of skin psoriasis is presented and discussed.
Author(s): Ritchlin CT, Pennington SR, Reynolds NJ, FitzGerald O
Publication type: Article
Publication status: Published
Journal: Journal of Rheumatology
Print publication date: 01/06/2020
Online publication date: 01/06/2020
Acceptance date: 02/04/2018
ISSN (print): 0380-0903
ISSN (electronic): 1499-2752
Publisher: The Journal of Rheumatology Publishing Co. Ltd
PubMed id: 32482763
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