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Circulating proteomic signatures of chronological age

Lookup NU author(s): Dr Ana ViñuelaORCiD



This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).


© The Author 2014. Published by Oxford University Press on behalf of The Gerontological Society of America.To elucidate the proteomic features of aging in plasma, the subproteome targeted by the SOMAscan assay was profiled in blood samples from 202 females from the TwinsUK cohort. Findings were replicated in 677 independent individuals from the AddNeuroMed, Alzheimer's Research UK, and Dementia Case Registry cohorts. Results were further validated using RNAseq data from whole blood in TwinsUK and the most significant proteins were tested for association with aging-related phenotypes after adjustment for age. Eleven proteins were associated with chronological age and were replicated at protein level in an independent population. These were further investigated at gene expression level in 384 females from the TwinsUK cohort. The two most strongly associated proteins were chordin-like protein 1 (meta-analysis β [SE] = 0.013 [0.001], p = 3.66 × 10-46) and pleiotrophin (0.012 [0.005], p = 3.88 × 10-41). Chordin-like protein 1 was also significantly correlated with birthweight (0.06 [0.02], p = 0.005) and with the individual Framingham 10-years cardiovascular risk scores in TwinsUK (0.71 [0.18], p = 9.9 × 10-5). Pleiotrophin is a secreted growth factor with a plethora of functions in multiple tissues and known to be a marker for cardiovascular risk and osteoporosis. Our study highlights the importance of proteomics to identify some molecular mechanisms involved in human health and aging.

Publication metadata

Author(s): Menni C, Kiddle SJ, Mangino M, Vinuela A, Psatha M, Steves C, Sattlecker M, Buil A, Newhouse S, Nelson S, Williams S, Voyle N, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S, Spector TD, Dobson R, Valdes AM

Publication type: Article

Publication status: Published

Journal: Journals of Gerontology: Series A - Biological Sciences and Medical Sciences

Year: 2015

Volume: 70

Issue: 7

Pages: 809-816

Print publication date: 01/07/2021

Online publication date: 14/08/2014

Acceptance date: 24/06/2014

Date deposited: 29/06/2020

ISSN (print): 1079-5006

ISSN (electronic): 1758-535X

Publisher: Oxford University Press


DOI: 10.1093/gerona/glu121

PubMed id: 25123647


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Funder referenceFunder name
EurHEALTHAging 277849
Wellcome Trust