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From the sea to the bee: Gellan gum-honey-diatom composite to deliver resveratrol for cartilage regeneration under oxidative stress conditions

Lookup NU author(s): Dr Piergiorgio GentileORCiD, Dr Annachiara ScalzoneORCiD



This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).


© 2020 Elsevier LtdCarbohydrate-based porous scaffolds are promising biomaterials to support cartilage regeneration. In this respect, their composition could be designed to face clinical challenges, i.e., articular load bearing, infections and oxidative stress. Herein, an innovative scaffold has been developed, combining raw materials belonging to different kingdoms of life. Indeed, gellan gum, a bacterial-derived carbohydrate, was blended with a beehive product (Manuka honey) with prominent antibacterial features. Moreover, resveratrol, a phytoalexin with powerful antioxidant activity, was loaded into the silica shells of diatoms, unicellular microalgae with cytocompatible features. The developed composite porous scaffolds demonstrated mechanical properties suitable for cartilage regeneration. Furthermore, they allowed the controlled release of resveratrol, hindering bacterial proliferation and oxidative stress damage, while supporting stem cell colonization and chondrogenic differentiation.

Publication metadata

Author(s): Bonifacio MA, Cochis A, Cometa S, Gentile P, Scalzone A, Scalia AC, Rimondini L, De Giglio E

Publication type: Article

Publication status: Published

Journal: Carbohydrate Polymers

Year: 2020

Volume: 245

Online publication date: 15/05/2020

Acceptance date: 03/05/2020

Date deposited: 14/07/2020

ISSN (print): 0144-8617

ISSN (electronic): 1879-1344

Publisher: Elsevier Ltd


DOI: 10.1016/j.carbpol.2020.116410


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