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Lookup NU author(s): Dr Piergiorgio GentileORCiD,
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
© 2020 Elsevier LtdCarbohydrate-based porous scaffolds are promising biomaterials to support cartilage regeneration. In this respect, their composition could be designed to face clinical challenges, i.e., articular load bearing, infections and oxidative stress. Herein, an innovative scaffold has been developed, combining raw materials belonging to different kingdoms of life. Indeed, gellan gum, a bacterial-derived carbohydrate, was blended with a beehive product (Manuka honey) with prominent antibacterial features. Moreover, resveratrol, a phytoalexin with powerful antioxidant activity, was loaded into the silica shells of diatoms, unicellular microalgae with cytocompatible features. The developed composite porous scaffolds demonstrated mechanical properties suitable for cartilage regeneration. Furthermore, they allowed the controlled release of resveratrol, hindering bacterial proliferation and oxidative stress damage, while supporting stem cell colonization and chondrogenic differentiation.
Author(s): Bonifacio MA, Cochis A, Cometa S, Gentile P, Scalzone A, Scalia AC, Rimondini L, De Giglio E
Publication type: Article
Publication status: Published
Journal: Carbohydrate Polymers
Online publication date: 15/05/2020
Acceptance date: 03/05/2020
Date deposited: 14/07/2020
ISSN (print): 0144-8617
ISSN (electronic): 1879-1344
Publisher: Elsevier Ltd
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