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Multitarget Approaches against Multiresistant Superbugs

Lookup NU author(s): Dr Declan Gray

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

Despite efforts to develop new antibiotics, antibacterial resistance still develops too fast for drug discovery to keep pace. Often, resistance against a new drug develops even before it reaches the market. This continued resistance crisis has demonstrated that resistance to antibiotics with single protein targets develops too rapidly to be sustainable. Most successful long-established antibiotics target more than one molecule or possess targets, which are encoded by multiple genes. This realization has motivated a change in antibiotic development toward drug candidates with multiple targets. Some mechanisms of action presuppose multiple targets or at least multiple effects, such as targeting the cytoplasmic membrane or the carrier molecule bactoprenol phosphate and are therefore particularly promising. Moreover, combination therapy approaches are being developed to break antibiotic resistance or to sensitize bacteria to antibiotic action. In this Review, we provide an overview of antibacterial multitarget approaches and the mechanisms behind them.

Publication metadata

Author(s): Gray DA, Wenzel M

Publication type: Article

Publication status: Published

Journal: ACS Infectious Diseases

Year: 2020

Volume: 6

Issue: 6

Pages: 1346-1365

Print publication date: 12/06/2020

Online publication date: 10/03/2020

Acceptance date: 01/01/2020

Date deposited: 25/06/2020

ISSN (electronic): 2373-8227

Publisher: American Chemical Society

URL: https://doi.org/10.1021/acsinfecdis.0c00001

DOI: 10.1021/acsinfecdis.0c00001

PubMed id: 32156116

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