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Stem cell-derived enteroid cultures as a tool for dissecting host-parasite interactions in the small intestinal epithelium

Lookup NU author(s): Professor Christopher StewartORCiD

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This is the authors' accepted manuscript of an article that has been published in its final definitive form by Wiley, 2021.

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Abstract

This article is protected by copyright. All rights reserved.Toxoplasma gondii and Cryptosporidium spp. can cause devastating pathological effects in humans and livestock, and in particular to young or immunocompromised individuals. The current treatment plans for these enteric parasites are limited due to long drug courses, severe side effects, or simply a lack of efficacy. The study of the early interactions between the parasites and the site of infection in the small intestinal epithelium has been thwarted by the lack of accessible, physiologically relevant, and species-specific models. Increasingly, 3D stem cell-derived enteroid models are being refined and developed into sophisticated models of infectious disease. In this review we shall illustrate the use of enteroids to spearhead research into enteric parasitic infections, bridging the gap between cell line cultures and in vivo experiments.

Publication metadata

Author(s): Hares MF, Tiffney EA, Johnston LJ, Luu L, Stewart CJ, Flynn RJ, Coombes JL

Publication type: Article

Publication status: Published

Journal: Parasite Immunology

Year: 2021

Volume: 43

Issue: 2

Print publication date: 01/02/2021

Online publication date: 21/06/2020

Acceptance date: 21/06/2020

Date deposited: 05/08/2020

ISSN (print): 0141-9838

ISSN (electronic): 1365-3024

Publisher: Wiley

URL: https://doi.org/10.1111/pim.12765

DOI: 10.1111/pim.12765

Data Access Statement: The data that support the findings of this study are available from the corresponding author upon reasonable request.

PubMed id: 32564379

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