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Lookup NU author(s): Dr Christopher Stewart
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This article is protected by copyright. All rights reserved.Toxoplasma gondii and Cryptosporidium spp. can cause devastating pathological effects in humans and livestock, and in particular to young or immunocompromised individuals. The current treatment plans for these enteric parasites are limited due to long drug courses, severe side effects, or simply a lack of efficacy. The study of the early interactions between the parasites and the site of infection in the small intestinal epithelium has been thwarted by the lack of accessible, physiologically relevant, and species-specific models. Increasingly, 3D stem cell-derived enteroid models are being refined and developed into sophisticated models of infectious disease. In this review we shall illustrate the use of enteroids to spearhead research into enteric parasitic infections, bridging the gap between cell line cultures and in vivo experiments.
Author(s): Hares MF, Tiffney EA, Johnston LJ, Luu L, Stewart CJ, Flynn RJ, Coombes JL
Publication type: Article
Publication status: Published
Journal: Parasite Immunology
Print publication date: 01/02/2021
Online publication date: 21/06/2020
Acceptance date: 21/06/2020
ISSN (print): 0141-9838
ISSN (electronic): 1365-3024
PubMed id: 32564379
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