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Lookup NU author(s): Dr Oliver Shannon,
Professor Bloss Stephan,
Dr Keith Gray,
Dr Stella PaddickORCiD,
Professor Richard Walker,
Dr Mario Siervo
This is the authors' accepted manuscript of an article that has been published in its final definitive form by Taylor and Francis Ltd, 2021.
For re-use rights please refer to the publisher's terms and conditions.
© 2020, © 2020 Taylor & Francis Group, LLC. Sub-Saharan African countries are experiencing an alarming increase in hypertension prevalence. This study evaluated the feasibility and acceptability of nitrate-rich beetroot and folate supplementation, alone or combined, for the reduction of blood pressure (BP) in Tanzanian adults with elevated BP. This was a three-arm double-blind, placebo-controlled, parallel randomised clinical trial. Forty-eight participants were randomised to one of three groups to follow a specific 60-day intervention which included a: (1) combined intervention (beetroot juice + folate), (2) single intervention (beetroot juice + placebo), and (3) control group (nitrate-depleted beetroot juice + placebo). Forty-seven participants (age: 50–70 years) completed the study. The acceptability of the interventions was high. Self-reported compliance to the interventions was more than 90% which was confirmed by the significant increase in nitrate and folate concentrations in plasma and saliva samples in the treatment arms. This study provides important information for the design of high-nitrate interventions to reduce BP in Sub-Saharan African countries.
Author(s): Kandhari N, Prabhakar M, Shannon O, Fostier W, Koehl C, Rogathi J, Temu G, Stephan BCM, Gray WK, Haule I, Paddick S-M, Mmbaga BT, Walker R, Siervo M
Publication type: Article
Publication status: Published
Journal: International Journal of Food Sciences and Nutrition
Online publication date: 10/06/2020
Acceptance date: 25/05/2020
Date deposited: 13/08/2020
ISSN (print): 0963-7486
ISSN (electronic): 1465-3478
Publisher: Taylor and Francis Ltd
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