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Inhibitors of JmjC-containing Histone Demethylases: Structural Perspective

Lookup NU author(s): Professor Akane Kawamura



This is the authors' accepted manuscript of a book chapter that has been published in its final definitive form by Springer International Publishing, 2020.

For re-use rights please refer to the publisher's terms and conditions.


Histone demethylases (KDMs) catalyse the removal of N-methyl marks on histones and play important roles in epigenetic regulation. Abnormal histone methylation and dysregulation of KDMs have been linked to multiple diseases, and KDMs are emerging as promising therapeutic targets. This chapter provides an overview of JmjC-domain-containing KDMs (JmjC-KDMs), with a particular focus on recent advances in JmjC-KDM inhibitor development from a structural perspective.

Publication metadata

Author(s): Wright M, Brennan P, Kawamura A

Editor(s): Antonello Mai

Publication type: Book Chapter

Publication status: Published

Book Title: Chemical Epigenetics

Year: 2020

Volume: 33

Pages: 221-253

Print publication date: 15/01/2020

Online publication date: 14/01/2020

Acceptance date: 01/07/2019

Series Title: Topics in Medicinal Chemistry

Publisher: Springer International Publishing

Place Published: Cham


DOI: 10.1007/7355_2019_75

Notes: 9783030429812 Hardback ISBN

Library holdings: Search Newcastle University Library for this item

ISBN: 9783030429829