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Lookup NU author(s): Professor Akane Kawamura
This is the authors' accepted manuscript of a book chapter that has been published in its final definitive form by Springer Nature, 2020.
For re-use rights please refer to the publisher's terms and conditions.
DNA methylation and its oxidised forms participate in the interpretation and regulation of the human genome. Many questions arise around the enzymes responsible for these chemical modifications on DNA, and their roles in transcriptional regulation. These epigenetic marks are very dynamic and specific in their location and context (tissues, diseases, etc.). We review the major enzymes involved in DNA methylation and oxidation, with a focus on the DNA methyltransferases and TET enzymes. The principal compounds that inhibit these enzymes are presented since they will help address these questions.
Author(s): Belle R, Kawamura A, Arimondo P
Editor(s): Antonello Mai
Publication type: Book Chapter
Publication status: Published
Book Title: Chemical Epigenetics
Print publication date: 01/04/2020
Online publication date: 24/10/2019
Acceptance date: 01/07/2019
Series Title: Topics in Medicinal Chemistry
Publisher: Springer Nature
Place Published: Cham
Notes: 9783030429812 Hardback
Library holdings: Search Newcastle University Library for this item