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Chemical compounds targeting DNA methylation and hydroxymethylation

Lookup NU author(s): Professor Akane Kawamura



This is the authors' accepted manuscript of a book chapter that has been published in its final definitive form by Springer Nature, 2020.

For re-use rights please refer to the publisher's terms and conditions.


DNA methylation and its oxidised forms participate in the interpretation and regulation of the human genome. Many questions arise around the enzymes responsible for these chemical modifications on DNA, and their roles in transcriptional regulation. These epigenetic marks are very dynamic and specific in their location and context (tissues, diseases, etc.). We review the major enzymes involved in DNA methylation and oxidation, with a focus on the DNA methyltransferases and TET enzymes. The principal compounds that inhibit these enzymes are presented since they will help address these questions.

Publication metadata

Author(s): Belle R, Kawamura A, Arimondo P

Editor(s): Antonello Mai

Publication type: Book Chapter

Publication status: Published

Book Title: Chemical Epigenetics

Year: 2020

Volume: 33

Pages: 255-286

Print publication date: 01/04/2020

Online publication date: 24/10/2019

Acceptance date: 01/07/2019

Series Title: Topics in Medicinal Chemistry

Publisher: Springer Nature

Place Published: Cham


DOI: 10.1007/7355_2019_76

Notes: 9783030429812 Hardback

Library holdings: Search Newcastle University Library for this item

ISBN: 9783030429829